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    alaA glutamate--pyruvate aminotransferase AlaA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946772, updated on 3-Dec-2024

    Summary

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    Official Symbol
    alaA
    Official Full Name
    glutamate--pyruvate aminotransferase AlaA
    Primary source
    ECOCYC:G7184
    Locus tag
    b2290
    See related
    ASAP:ABE-0007560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2284; yfbQ
    Summary
    AFMB Structural Genomics target Number 1 (http://afmb.cnrs-mrs.fr/article171. [More information is available at EcoGene: EG14101].
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    Genomic context

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    Sequence:
    NC_000913.3 (2407561..2408778)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH:quinone oxidoreductase subunit A Neighboring gene DNA-binding transcriptional dual regulator LrhA Neighboring gene dCMP phosphohydrolase Neighboring gene putative transporter YfbS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a mutant auxotrophic for L-alanine and identification of three major aminotransferases that synthesize L-alanine in Escherichia coli. Yoneyama H, et al. Biosci Biotechnol Biochem, 2011. PMID 21597182
    2. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli. Peña-Soler E, et al. PLoS One, 2014. PMID 25014014, Free PMC Article
    3. Cloning of genes that suppress an Escherichia coli K-12 alanine auxotroph when present in multicopy plasmids. Wang MD, et al. J Bacteriol, 1987 Dec. PMID 2890623, Free PMC Article
    4. Escherichia coli genes that reduce the lethal effects of stress. Han X, et al. BMC Microbiol, 2010 Feb 4. PMID 20128927, Free PMC Article
    5. Genetics and regulation of the major enzymes of alanine synthesis in Escherichia coli. Kim SH, et al. J Bacteriol, 2010 Oct. PMID 20729367, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
      Title: Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-alanine:2-oxoglutarate aminotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-alanine:2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-alanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-alanine biosynthetic process from pyruvate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within L-alanine biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within alanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate--pyruvate aminotransferase AlaA
    NP_416793.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2407561..2408778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416793.1 glutamate--pyruvate aminotransferase AlaA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416793.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FQ26
      Conserved Domains (1) summary
      PRK09265
      Location:1 → 404
      PRK09265; aminotransferase AlaT; Validated
    Nucleotide Protein
    Heading Accession and Version

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