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    pta phosphate acetyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946778, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pta
    Official Full Name
    phosphate acetyltransferase
    Primary source
    ECOCYC:EG20173
    Locus tag
    b2297
    See related
    ASAP:ABE-0007582
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2291
    Summary
    HT_Cmplx21_Cyt: [More information is available at EcoGene: EG20173].
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    Genomic context

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    Sequence:
    NC_000913.3 (2414747..2416891)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04217 family membrane protein YfbV Neighboring gene acetate kinase Neighboring gene putative transporter YfcC Neighboring gene putative Nudix hydrolase YfcD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphotransacetylase of Escherichia coli B, activation by pyruvate and inhibition by NADH and certain nucleotides. Suzuki T. Biochim Biophys Acta, 1969. PMID 4312205
    2. Purification of phosphotransacetylase from Escherichia coli, K-12. GOLDMAN DS. Biochim Biophys Acta, 1958 May. PMID 13535743
    3. Phosphotransacetylase as a key factor in biological production of polyhydroxybutyrate. Miyake M, et al. Appl Biochem Biotechnol, 2000 Spring. PMID 10849856
    4. Acetate metabolism in a pta mutant of Escherichia coli W3110: importance of maintaining acetyl coenzyme A flux for growth and survival. Chang DE, et al. J Bacteriol, 1999 Nov. PMID 10542166, Free PMC Article
    5. The glucose-starvation stimulon of Escherichia coli: induced and repressed synthesis of enzymes of central metabolic pathways and role of acetyl phosphate in gene expression and starvation survival. Nyström T. Mol Microbiol, 1994 Jun. PMID 8052134

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acetate and glucose fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway.
      Title: Acetate fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway.
    2. Pta gene deletion increases L-tryptophan production.
      Title: [Effects of gene pta disruption on L-tryptophan fermentation].
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Nucleotide sequence of the phosphotransacetylase gene of Escherichia coli strain K12.
    4. pta/ackA recF mutants are viable, suggesting, together with the inviability of pta/ackA recBC mutants, that chromosomal lesions due to the pta/ackA defect are of the double-strand-break type.
      Title: A defect in the acetyl coenzyme A<-->acetate pathway poisons recombinational repair-deficient mutants of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphate acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-threonine catabolic process to propionate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within acetate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within acetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in acetate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in acetyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within acetyl-CoA biosynthetic process from acetate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphate acetyltransferase
    NP_416800.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2414747..2416891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416800.1 phosphate acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416800.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAI9GV52
      Conserved Domains (1) summary
      PRK05632
      Location:1 → 711
      PRK05632; phosphate acetyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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