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    pyrR DNA-binding transcriptional activator PyrR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947395, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pyrR
    Official Full Name
    DNA-binding transcriptional activator PyrR
    Primary source
    ECOCYC:G7244
    Locus tag
    b2381
    See related
    ASAP:ABE-0007857
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2377; ypdB
    Summary
    YpdAB may be a cognate two-component system sensor-regulator pair. [More information is available at EcoGene: EG14149]. A mutant containing a deletion of both ypdA and ypdB does not show a significant phenotype when measured by phenotype microarray . [More information is available at EcoCyc: G7244].
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    Genomic context

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    Sequence:
    NC_000913.3 (2500383..2501117)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutamate--pyruvate aminotransferase AlaC Neighboring gene sensor histidine kinase PyrS Neighboring gene putative AraC-type DNA-binding transcriptional regulator YpdC Neighboring gene putative PTS multiphosphoryl transfer protein FryA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulatory roles of pyruvate-sensing two-component system PyrSR (YpdAB) in Escherichia coli K-12. Miyake Y, et al. FEMS Microbiol Lett, 2019 Jan 1. PMID 30624637
    2. A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance. Vilhena C, et al. J Bacteriol, 2018 Jan 1. PMID 29038258, Free PMC Article
    3. Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa H, et al. J Bacteriol, 2003 Mar. PMID 12618449, Free PMC Article
    4. Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems. Zhou L, et al. J Bacteriol, 2003 Aug. PMID 12897016, Free PMC Article
    5. Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12. Oshima T, et al. Mol Microbiol, 2002 Oct. PMID 12366850

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. For induction of YpdAB function, the major exometabolite pyruvate in growing E. coli K-12 was identified as the inducer.
      Title: Regulatory roles of pyruvate-sensing two-component system PyrSR (YpdAB) in Escherichia coli K-12.
    2. findings suggest that the BtsS/BtsR and YpdA/YpdB network contributes to a balancing of the physiological state of all cells within a population
      Title: A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator PyrR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2500383..2501117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416882.1 DNA-binding transcriptional activator PyrR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416882.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AI82
      Conserved Domains (1) summary
      COG3279
      Location:1 → 244
      LytT; DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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