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    pdeA putative c-di-GMP phosphodiesterase PdeA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946864, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pdeA
    Official Full Name
    putative c-di-GMP phosphodiesterase PdeA
    Primary source
    ECOCYC:EG11145
    Locus tag
    b2395
    See related
    ASAP:ABE-0007899
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2389; yfeA
    Summary
    YfeA has a central GGDEF putative diguanylate cyclase, then a C-terminal putative cyclic-di-GMP phosphodiesterase EAL domain. [More information is available at EcoGene: EG11145].
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    Genomic context

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    Sequence:
    NC_000913.3 (2515643..2517832, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleoside:H(+) symporter NupC Neighboring gene putative IS186/IS421 transposase Neighboring gene tRNA-Ala Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Reinders A, et al. J Bacteriol, 2016 Feb 1. PMID 26553851, Free PMC Article
    2. Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. Brun YV, et al. J Mol Biol, 1990 Aug 20. PMID 2201776
    3. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
    4. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833
    5. Characterization of the rdar morphotype, a multicellular behaviour in Enterobacteriaceae. Römling U. Cell Mol Life Sci, 2005 Jun. PMID 15818467, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cyclic-guanylate-specific phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic-guanylate-specific phosphodiesterase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative c-di-GMP phosphodiesterase PdeA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2515643..2517832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416896.4 putative c-di-GMP phosphodiesterase PdeA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416896.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A830SF13
      Conserved Domains (3) summary
      smart00267
      Location:324 → 473
      GGDEF; diguanylate cyclase
      smart00052
      Location:493 → 729
      EAL; Putative diguanylate phosphodiesterase
      pfam05231
      Location:15 → 311
      MASE1
    Nucleotide Protein
    Heading Accession and Version

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