U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    xapA xanthosine phosphorylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946878, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    xapA
    Official Full Name
    xanthosine phosphorylase
    Primary source
    ECOCYC:G85
    Locus tag
    b2407
    See related
    ASAP:ABE-0007927
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2401; pndA
    Summary
    Guanosine and inosine are also substrates for XapA. [More information is available at EcoGene: EG20250]. The trimeric form is also active with less substrate specificity. [More information is available at EcoCyc: G85].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2524045..2524878, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator XapR Neighboring gene xanthosine:H(+) symporter XapB Neighboring gene putative outer membrane porin YfeN Neighboring gene putative DNA-binding transcriptional regulator YfeR

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide. Dong WR, et al. BMC Microbiol, 2014 Feb 8. PMID 24506841, Free PMC Article
    2. A second purine nucleoside phosphorylase in Escherichia coli K-12. II. Properties of xanthosine phosphorylase and its induction by xanthosine. Hammer-Jespersen K, et al. Mol Gen Genet, 1980. PMID 7007809
    3. Purification and properties of inosine-guanosine phosphorylase from Escherichia coli K-12. Koszalka GW, et al. J Bacteriol, 1988 Aug. PMID 3042752, Free PMC Article
    4. Effects of xapA and guaA disruption on inosine accumulation in Escherichia coli. Shimaoka M, et al. Biosci Biotechnol Biochem, 2006 Dec. PMID 17151449
    5. Escherichia coli purine nucleoside phosphorylase II, the product of the xapA gene. Dandanell G, et al. J Mol Biol, 2005 Apr 22. PMID 15808857

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inosine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within NAD salvage EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in deoxyguanosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deoxyinosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in guanosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleobase-containing small molecule interconversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleobase-containing small molecule metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein hexamerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleoside catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleoside catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xanthosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    xanthosine phosphorylase
    NP_416902.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2524045..2524878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416902.1 xanthosine phosphorylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416902.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A775UUF4, A0A7A2QW49
      Conserved Domains (1) summary
      PRK08202
      Location:13 → 276
      PRK08202; purine nucleoside phosphorylase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.