U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hycH formate hydrogenlyase assembly protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947438, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hycH
    Official Full Name
    formate hydrogenlyase assembly protein
    Primary source
    ECOCYC:EG10481
    Locus tag
    b2718
    See related
    ASAP:ABE-0008933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2713; hevH
    Summary
    FhlA regulon. [More information is available at EcoGene: EG10481]. The HycH protein does not appear to be part of the functional formate hydrogenlyase complex, but is required for maturation of hydrogenase 3 . [More information is available at EcoCyc: EG10481].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2843036..2843446, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene beta-glucoside specific PTS enzyme IIBC component Neighboring gene 6-phospho-beta-glucosidase AscB Neighboring gene hydrogenase 3 maturation protease Neighboring gene formate hydrogenlyase subunit HycG Neighboring gene formate hydrogenlyase subunit HycF Neighboring gene formate hydrogenlyase subunit HycE

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli. Hopper S, et al. J Biol Chem, 1994 Jul 29. PMID 8034728
    2. Nucleotide sequence and expression of an operon in Escherichia coli coding for formate hydrogenlyase components. Böhm R, et al. Mol Microbiol, 1990 Feb. PMID 2187144
    3. The dual-function chaperone HycH improves assembly of the formate hydrogenlyase complex. Lindenstrauß U, et al. Biochem J, 2017 Aug 11. PMID 28718449
    4. Mutational analysis of the operon (hyc) determining hydrogenase 3 formation in Escherichia coli. Sauter M, et al. Mol Microbiol, 1992 Jun. PMID 1625581
    5. Characterisation of a protease from Escherichia coli involved in hydrogenase maturation. Rossmann R, et al. Eur J Biochem, 1995 Jan 15. PMID 7851435

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data presented here show that HycH has a novel dual role as an assembly chaperone for a cytoplasmic [NiFe]-hydrogenase.
      Title: The dual-function chaperone HycH improves assembly of the formate hydrogenlyase complex.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    formate hydrogenlyase assembly protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2843036..2843446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417198.1 formate hydrogenlyase assembly protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417198.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MGP2
      Conserved Domains (1) summary
      PRK15084
      Location:1 → 134
      PRK15084; formate hydrogenlyase maturation protein HycH; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.