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    scpA methylmalonyl-CoA mutase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945576, updated on 3-Dec-2024

    Summary

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    Official Symbol
    scpA
    Official Full Name
    methylmalonyl-CoA mutase
    Primary source
    ECOCYC:EG11444
    Locus tag
    b2917
    See related
    ASAP:ABE-0009577
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2913; sbm; yliK
    Summary
    Part of a four gene operon encoding enzymes converting succinate to propionate. [More information is available at EcoGene: EG11444]. Methylmalonyl-CoA mutase (MCM) catalyzes the reversible, stereospecific interconversion of methylmalonyl-CoA to succinyl-CoA . [More information is available at EcoCyc: EG11444].
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    Genomic context

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    Sequence:
    NC_000913.3 (3060850..3062994)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DNA-binding transcriptional dual regulator ArgP Neighboring gene methylmalonyl-CoA mutase-interacting GTPase YgfD Neighboring gene methylmalonyl-CoA decarboxylase Neighboring gene propionyl-CoA:succinate CoA transferase Neighboring gene putative DNA-binding transcriptional regulator YgfI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HPLC assay for methylmalonyl-CoA epimerase. Bobik TA, et al. Anal Bioanal Chem, 2003 Feb. PMID 12589497
    2. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Dayem LC, et al. Biochemistry, 2002 Apr 23. PMID 11955068
    3. Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli. Froese DS, et al. Microbiol Res, 2009. PMID 18950999, Free PMC Article
    4. MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation. Korotkova N, et al. J Biol Chem, 2004 Apr 2. PMID 14734568
    5. Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar typhimurium. Aldor IS, et al. Appl Environ Microbiol, 2002 Aug. PMID 12147480, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sbm is expressed and interacts with ygfD in Escherichia coli.
      Title: Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cobalamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cobalamin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalamin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylmalonyl-CoA mutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylmalonyl-CoA mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylmalonyl-CoA mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in propionate metabolic process, methylmalonyl pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methylmalonyl-CoA mutase
    NP_417392.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3060850..3062994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417392.1 methylmalonyl-CoA mutase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417392.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376TST4, A0A7L7EHC1
      Conserved Domains (1) summary
      PRK09426
      Location:1 → 714
      PRK09426; methylmalonyl-CoA mutase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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