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    mscS small conductance mechanosensitive channel MscS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947416, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mscS
    Official Full Name
    small conductance mechanosensitive channel MscS
    Primary source
    ECOCYC:EG11160
    Locus tag
    b2924
    See related
    ASAP:ABE-0009595
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2920; yggB
    Summary
    HT_Cmplx47_Mem: [More information is available at EcoGene: EG11160]. MscS is one of four classes of Escherichia coli mechanosensitive (MS) channels. [More information is available at EcoCyc: EG11160].
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    Genomic context

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    Sequence:
    NC_000913.3 (3068947..3069807, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF541 domain-containing protein YggE Neighboring gene L-arginine exporter Neighboring gene fructose-bisphosphate aldolase class II Neighboring gene phosphoglycerate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance. Spronk SA, et al. Biophys J, 2006 May 15. PMID 16500980, Free PMC Article
    2. Pore mutations of the Escherichia coli MscS channel affect desensitization but not ionic preference. Edwards MD, et al. Biophys J, 2008 Apr 15. PMID 18065458, Free PMC Article
    3. Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS. Akitake B, et al. Nat Struct Mol Biol, 2007 Dec. PMID 18037888
    4. Characterization of the resting MscS: modeling and analysis of the closed bacterial mechanosensitive channel of small conductance. Anishkin A, et al. Biophys J, 2008 Feb 15. PMID 17981908, Free PMC Article
    5. The role of tryptophan residues in the function and stability of the mechanosensitive channel MscS from Escherichia coli. Rasmussen A, et al. Biochemistry, 2007 Sep 25. PMID 17718516

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels.
      Title: State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels.
    2. Interaction between mechanosensitive channels embedded in lipid membrane.
      Title: Interaction between mechanosensitive channels embedded in lipid membrane.
    3. inactivation process of wild-type MscS was strongly affected by voltage. The wild-type MscS inactivated at +60 to +80 mV but not at -60 to +40 mV.
      Title: Voltage-Dependent Inactivation of MscS Occurs Independently of the Positively Charged Residues in the Transmembrane Domain.
    4. Mutations in a conserved domain of E. coli MscS to the most conserved superfamily residue leads to kinetic changes.
      Title: Mutations in a Conserved Domain of E. coli MscS to the Most Conserved Superfamily Residue Leads to Kinetic Changes.
    5. Molecular dynamics and biophysical analyses show that the volume of the pockets and thus the number of lipid acyl chains within them decreases upon channel opening.
      Title: The role of lipids in mechanosensation.
    6. Data show that trifluoroethanol (TFE) affects mechanosensitive channel of small conductance (MscS) channel gating kinetics in spheroplasts and liposomes.
      Title: Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes.
    7. Data indicate that mechanosensitive channel of small conductance (MscS) protein opens in response to a relief of intrinsic lipid bilayer pressure.
      Title: The mechanosensitive channel of small conductance (MscS) functions as a Jack-in-the box.
    8. We report here crystal structures of MscS from E. coli and Helicobacter pylori solubilized in the detergent beta-dodecylmaltoside at resolutions of 4.4 and 4.2 A, respectively.
      Title: Open and shut: crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance from Escherichia coli and Helicobacter pylori at 4.4 Å and 4.1 Å resolutions.
    9. Article reviews the science that led to the isolation and identification of MscS. structure-function relationship of the channel, in particular the structural and biochemical approaches to understanding channel gating. [Review]
      Title: Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.
    10. Data show that the MscL/MscS threshold ratio dramatically decreased in thinner compared with thicker bilayers.
      Title: Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small conductance mechanosensitive channel MscS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3068947..3069807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417399.1 small conductance mechanosensitive channel MscS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417399.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A793CB35
      Conserved Domains (1) summary
      PRK10334
      Location:1 → 286
      PRK10334; small-conductance mechanosensitive channel MscS
    Nucleotide Protein
    Heading Accession and Version

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