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    epd D-erythrose-4-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947413, updated on 3-Dec-2024

    Summary

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    Official Symbol
    epd
    Official Full Name
    D-erythrose-4-phosphate dehydrogenase
    Primary source
    ECOCYC:EG10368
    Locus tag
    b2927
    See related
    ASAP:ABE-0009607
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2923; gap2; gapB
    Summary
    The enzyme is composed of 4 monomers of 37.2 kDa each . [More information is available at EcoCyc: EG10368].
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    Genomic context

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    Sequence:
    NC_000913.3 (3072672..3073691, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fructose-bisphosphate aldolase class II Neighboring gene phosphoglycerate kinase Neighboring gene P-loop NTPase domain-containing protein YggC Neighboring gene fumarase E Neighboring gene fructose 1,6-bisphosphatase YggF Neighboring gene putative zinc-binding dehydrogenase YggP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. Yang Y, et al. J Bacteriol, 1998 Aug. PMID 9696782, Free PMC Article
    2. Characterization of Escherichia coli strains with gapA and gapB genes deleted. Seta FD, et al. J Bacteriol, 1997 Aug. PMID 9260967, Free PMC Article
    3. A naturally occurring horizontal gene transfer from a eukaryote to a prokaryote. Doolittle RF, et al. J Mol Evol, 1990 Nov. PMID 2124629
    4. Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli. Bardey V, et al. Mol Microbiol, 2005 Sep. PMID 16102000
    5. The EIIGlc protein is involved in glucose-mediated activation of Escherichia coli gapA and gapB-pgk transcription. Charpentier B, et al. J Bacteriol, 1998 Dec. PMID 9851989, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.
    2. epd translation initiation region and ORF are adapted in order to limit epd translation and to create an efficient RNase E entry site.
      Title: Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables erythrose-4-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables erythrose-4-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pyridoxal phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pyridoxal phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyridoxal phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyridoxine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyridoxine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-erythrose-4-phosphate dehydrogenase
    NP_417402.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3072672..3073691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417402.1 D-erythrose-4-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417402.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FXI1
      Conserved Domains (1) summary
      PRK13535
      Location:2 → 334
      PRK13535; erythrose 4-phosphate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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