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    mltC membrane-bound lytic murein transglycosylase C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945428, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mltC
    Official Full Name
    membrane-bound lytic murein transglycosylase C
    Primary source
    ECOCYC:G7533
    Locus tag
    b2963
    See related
    ASAP:ABE-0009725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2958; yggZ
    Summary
    MltC should cleave the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG12986]. Escherichia coli contains a large number of murein hydrolase enzymes. [More information is available at EcoCyc: G7533].
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    Genomic context

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    Sequence:
    NC_000913.3 (3104433..3105512)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenine DNA glycosylase Neighboring gene putative Fe(2(+))-trafficking protein Neighboring gene nucleoside:H(+) symporter NupG Neighboring gene constitutive ornithine decarboxylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of new members of the lytic transglycosylase family in Haemophilus influenzae and Escherichia coli. Dijkstra AJ, et al. Microb Drug Resist, 1996 Spring. PMID 9158737
    2. From growth to autolysis: the murein hydrolases in Escherichia coli. Höltje JV. Arch Microbiol, 1995 Oct. PMID 7487333
    3. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Lee M, et al. J Am Chem Soc, 2013 Mar 6. PMID 23421439, Free PMC Article
    4. Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli. Korsak D, et al. Antimicrob Agents Chemother, 2005 Apr. PMID 15793119, Free PMC Article
    5. SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli. Pomposiello PJ, et al. J Bacteriol, 2003 Nov. PMID 14594836, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic endotransglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic transglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cell wall macromolecule catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to antibiotic EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidoglycan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane-bound lytic murein transglycosylase C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3104433..3105512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417438.2 membrane-bound lytic murein transglycosylase C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417438.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A140N675, A0A192CBL4, A0A1X3I2C2, A0A1X3JDM1, A0AA36P714, A0AAJ3NWM3, A0AAN3MCV3, D3GUM7, F4T2U1, J7Q9L2, W1EYP0
      Conserved Domains (1) summary
      PRK11671
      Location:1 → 359
      mltC; membrane-bound lytic murein transglycosylase MltC
    Nucleotide Protein
    Heading Accession and Version

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