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    ttdA L(+)-tartrate dehydratase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947565, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ttdA
    Official Full Name
    L(+)-tartrate dehydratase subunit alpha
    Primary source
    ECOCYC:EG11168
    Locus tag
    b3061
    See related
    ASAP:ABE-0010050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3051; ygjA
    Summary
    The ttdA gene encodes the alpha subunit of the L-tartrate dehydratase enzyme and is expressed in exponentially growing cells . [More information is available at EcoCyc: EG11168].
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    Genomic context

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    Sequence:
    NC_000913.3 (3206463..3207374)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative glycerol-3-phosphate acyltransferase Neighboring gene DNA-binding transcriptional activator Dan Neighboring gene L(+)-tartrate dehydratase subunit beta Neighboring gene L-tartrate:succinate antiporter Neighboring gene N(6)-L-threonylcarbamoyladenine synthase, TsaD subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the L-tartrate dehydratase genes (ttdA and ttdB) of Escherichia coli and evolutionary relationship with the class I fumarase genes. Reaney SK, et al. J Gen Microbiol, 1993 Jul. PMID 8371115
    2. Possible new genes as revealed by molecular analysis of a 5-kb Escherichia coli chromosomal region 5' to the rpsU-dnaG-rpoD macromolecular-synthesis operon. Nesin M, et al. Gene, 1987. PMID 3297921
    3. The L-tartrate/succinate antiporter TtdT (YgjE) of L-tartrate fermentation in Escherichia coli. Kim OB, et al. J Bacteriol, 2007 Mar. PMID 17172328, Free PMC Article
    4. Regulation of tartrate metabolism by TtdR and relation to the DcuS-DcuR-regulated C4-dicarboxylate metabolism of Escherichia coli. Kim OB, et al. Microbiology (Reading), 2009 Nov. PMID 19661178
    5. Functional identification of ygiP as a positive regulator of the ttdA-ttdB-ygjE operon. Oshima T, et al. Microbiology (Reading), 2006 Jul. PMID 16804186

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L(+)-tartrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tartrate catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within tartrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    L(+)-tartrate dehydratase subunit alpha
    NP_417533.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3206463..3207374
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417533.1 L(+)-tartrate dehydratase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417533.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN5FRY2
      Conserved Domains (1) summary
      PRK08230
      Location:6 → 303
      PRK08230; tartrate dehydratase subunit alpha; Validated
    Nucleotide Protein
    Heading Accession and Version

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