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    patA putrescine aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947120, updated on 3-Dec-2024

    Summary

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    Official Symbol
    patA
    Official Full Name
    putrescine aminotransferase
    Primary source
    ECOCYC:G7596
    Locus tag
    b3073
    See related
    ASAP:ABE-0010092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3063; oat; pat; ygjG
    Summary
    PatA(YgjG) and Prr(YdcW) form an alternative to the Puu pathway converting putrescine to gamma-aminobutyric acid (Samsonova, 2005). [More information is available at EcoGene: EG12718]. Putrescine transaminase catalyzes the first step in the putrescine degradative pathway, whereby putrescine is converted into 4-aminobutyrate via 4-aminobutyraldehyde . [More information is available at EcoCyc: G7596].
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    Genomic context

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    Sequence:
    NC_000913.3 (3219494..3220873)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor NfeR Neighboring gene aerotaxis receptor Neighboring gene putative tRNA-binding protein YgjH Neighboring gene DNA-binding transcriptional repressor EbgR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of putrescine aminotransferase from Escherichia coli provides insights into the substrate specificity among class III aminotransferases. Cha HJ, et al. PLoS One, 2014. PMID 25423189, Free PMC Article
    2. Two mechanisms for putrescine-dependent transcriptional expression of the putrescine aminotransferase gene, ygjG, in Escherichia coli. Kim YS, et al. Arch Microbiol, 2014 Sep. PMID 24906570
    3. Crystallization and preliminary X-ray crystallographic analysis of YgjG from Escherichia coli. Yeo SJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Sep 1. PMID 22949197, Free PMC Article
    4. PURIFICATION AND PROPERTIES OF A DIAMINE ALPHA-KETOGLUTARATE TRANSAMINASE FROM ESCHERICHIA COLI. KIM KH. J Biol Chem, 1964 Mar. PMID 14154456
    5. Control of utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12. Shaibe E, et al. J Bacteriol, 1985 Sep. PMID 3897202, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rpoS is required for putrescine-dependent ygjG-lacZ expression, but the effect of putrescine on this expression is not caused by simple modulation of RpoS synthesis
      Title: Two mechanisms for putrescine-dependent transcriptional expression of the putrescine aminotransferase gene, ygjG, in Escherichia coli.
    2. crystal belonged to the primitive orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 121.1, b = 129.5, c = 131.3 A, and is estimated to contain four molecules of YgjG per asymmetric unit
      Title: Crystallization and preliminary X-ray crystallographic analysis of YgjG from Escherichia coli.
    3. Expression of E. coli K12 ygjG coding region revealed sigma54-depended ORF which encodes a 459-amino acid protein with putrescine:2-OG aminotransferase activity.
      Title: Molecular cloning and characterization of Escherichia coli K12 ygjG gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables diamine transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables putrescine--2-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables putrescine--2-oxoglutarate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables putrescine--2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables putrescine--2-oxoglutarate transaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-lysine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in putrescine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within putrescine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within putrescine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putrescine aminotransferase
    NP_417544.5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3219494..3220873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417544.5 putrescine aminotransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417544.5

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9X3U5
      Conserved Domains (1) summary
      PRK11522
      Location:1 → 459
      PRK11522; putrescine--2-oxoglutarate aminotransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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