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    ebgA evolved beta-D-galactosidase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947583, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ebgA
    Official Full Name
    evolved beta-D-galactosidase subunit alpha
    Primary source
    ECOCYC:EG10252
    Locus tag
    b3076
    See related
    ASAP:ABE-0010104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3066
    Summary
    Wildtype EbgA can be mutated to hydrolyze lactose. [More information is available at EcoGene: EG10252]. The EbgA-EbgC complex represents the second -D-galactosidase enzyme in Escherichia coli. [More information is available at EcoCyc: EG10252].
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    Genomic context

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    Sequence:
    NC_000913.3 (3222633..3225725)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative tRNA-binding protein YgjH Neighboring gene DNA-binding transcriptional repressor EbgR Neighboring gene DUF386 domain-containing evolved beta-D-galactosidase subunit beta Neighboring gene putative transporter YgjI Neighboring gene protein YgjJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Experimental evolution of a new enzymatic function. II. Evolution of multiple functions for ebg enzyme in E. coli. Hall BG. Genetics, 1978 Jul. PMID 97169, Free PMC Article
    2. Probable mechanism of enzyme evolution: how did EBG of E. coli originate? Erhan S. Med Hypotheses, 1979 Nov. PMID 119900
    3. Experimental evolution of a new enzymatic function. Kinetic analysis of the ancestral (ebg) and evolved (ebg) enzymes. Hall BG. J Mol Biol, 1976 Oct 15. PMID 794482
    4. High-throughput screening of enzyme libraries: in vitro evolution of a beta-galactosidase by fluorescence-activated sorting of double emulsions. Mastrobattista E, et al. Chem Biol, 2005 Dec. PMID 16356846
    5. Evolution of a new enzymatic function by recombination within a gene. Hall BG, et al. Proc Natl Acad Sci U S A, 1980 Jun. PMID 6774339, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Catalysis by the large subunit of the second beta-galactosidase of Escherichia coli in the absence of the small subunit.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-galactosidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of beta-galactosidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    evolved beta-D-galactosidase subunit alpha

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3222633..3225725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026199.1 evolved beta-D-galactosidase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026199.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JR14
      Conserved Domains (1) summary
      PRK10340
      Location:1 → 1021
      ebgA; cryptic beta-D-galactosidase subunit alpha; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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