secG Sec translocon subunit SecG [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: secG
Official Full Name: Sec translocon subunit SecG
Primary source: ECOCYC:EG12095
Locus tag: b3175
See related: ASAP:ABE-0010436
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3164; prlH
Summary: SecYEG complex interacts with SecDFyajC to form a hexameric holocomplex. [More information is available at EcoGene: EG12095]. SecG is an inner membrane protein involved in the Sec protein secretion pathway. [More information is available at EcoCyc: EG12095].
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Genomic context

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Sequence:: NC_000913.3 (3322173..3322505, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
Title: Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
SecA gains access to the SecYEG complex via a lipid-bound intermediate state, whereas acidic phospholipids allosterically activate SecA for ATP-dependent protein translocation.
Title: Lipids Activate SecA for High Affinity Binding to the SecYEG Complex.
Authors show that SecG plays a critical role for the residual export mediated by mutant signal sequences and that the SecYE dimer can often be detected only in the presence of SecG.
Title: Escherichia coli SecG is required for residual export mediated by mutant signal sequences and for SecY-SecE complex stability.
The hydrophobicity threshold for SecYEG-mediated cell membrane insertion is distinctly lower than that for Sec61-mediated insertion.
Title: Quantitative analysis of SecYEG-mediated insertion of transmembrane α-helices into the bacterial inner membrane.
Data show that ribosome binding is sufficient to open the SecYEG channel.
Title: The bacterial translocon SecYEG opens upon ribosome binding.
Data indicate taht SecG inversion occurs only when MPIase associates with SecYEG.
Title: Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation.
Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli
Title: Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli.
The observed conformational changes thus position SecA for productive interaction with the SecYEG translocon and for transfer of segments of its passenger protein across the translocon
Title: Using a low denaturant model to explore the conformational features of translocation-active SecA.
SecA can promote protein translocation and ion channel activities both when it is bound to lipids at low affinity sites and when it is bound to SecYEG with high affinity.
Title: SecA alone can promote protein translocation and ion channel activity: SecYEG increases efficiency and signal peptide specificity.
analysis of conformational dynamics of the plug domain of the SecYEG protein-conducting channel
Title: Conformational dynamics of the plug domain of the SecYEG protein-conducting channel.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-transporting ATPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein insertion into membrane from inner side	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into membrane from inner side	IDA Inferred from Direct Assay more info	PubMed
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport by the Sec complex	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport by the Sec complex	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport by the Sec complex	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of cell envelope Sec protein transport complex	IDA Inferred from Direct Assay more info	PubMed
part_of cell envelope Sec protein transport complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sec translocon subunit SecG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

3322173..3322505 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417642.1 Sec translocon subunit SecG [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417642.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A376LEN0

Conserved Domains (1) summary

COG1314
Location:1 → 81

SecG; Preprotein translocase subunit SecG [Intracellular trafficking, secretion, and vesicular transport]