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    uspA universal stress protein A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948007, updated on 3-Dec-2024

    Summary

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    Official Symbol
    uspA
    Official Full Name
    universal stress protein A
    Primary source
    ECOCYC:EG11390
    Locus tag
    b3495
    See related
    ASAP:ABE-0011414
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3480
    Summary
    UspA is transcriptionally activated by ppGpp and repressed by FadR. [More information is available at EcoGene: EG11390]. UspA belongs to a superfamily of widely conserved proteins whose physiological function is unknown. [More information is available at EcoCyc: EG11390].
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    Genomic context

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    Sequence:
    NC_000913.3 (3640111..3640545)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene metal phosphate:H(+) symporter PitA Neighboring gene universal stress protein B Neighboring gene protein YriA Neighboring gene protein YriB Neighboring gene dipeptide/tripeptide:H(+) symporter DtpB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, mapping and nucleotide sequencing of a gene encoding a universal stress protein in Escherichia coli. Nyström T, et al. Mol Microbiol, 1992 Nov. PMID 1453957
    2. Isolation and properties of a mutant of Escherichia coli with an insertional inactivation of the uspA gene, which encodes a universal stress protein. Nyström T, et al. J Bacteriol, 1993 Jul. PMID 8391533, Free PMC Article
    3. Metabolic control of the Escherichia coli universal stress protein response through fructose-6-phosphate. Persson O, et al. Mol Microbiol, 2007 Aug. PMID 17640273
    4. Effects of overproducing the universal stress protein, UspA, in Escherichia coli K-12. Nyström T, et al. J Bacteriol, 1996 Feb. PMID 8550536, Free PMC Article
    5. The universal stress protein, UspA, of Escherichia coli is phosphorylated in response to stasis. Freestone P, et al. J Mol Biol, 1997 Dec 5. PMID 9405142

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The universal stress protein, UspA, of Escherichia coli is phosphorylated in response to stasis.
    2. The uspA gene is also regulated by an intermediate of the glycolytic/gluconeogenic pathways.
      Title: Metabolic control of the Escherichia coli universal stress protein response through fructose-6-phosphate.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    universal stress protein A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3640111..3640545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417952.1 universal stress protein A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417952.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FFE9
      Conserved Domains (1) summary
      PRK15118
      Location:1 → 144
      PRK15118; universal stress protein UspA
    Nucleotide Protein
    Heading Accession and Version

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