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    arsR DNA-binding transcriptional repressor ArsR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948013, updated on 3-Dec-2024

    Summary

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    Official Symbol
    arsR
    Official Full Name
    DNA-binding transcriptional repressor ArsR
    Primary source
    ECOCYC:EG12235
    Locus tag
    b3501
    See related
    ASAP:ABE-0011435
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    arsE; ECK3486
    Summary
    ArsR negatively controls the expression of the genes involved in arsenical and antimonite metals resistance whose expression is induced in the presence of these metals . [More information is available at EcoCyc: EG12235].
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    Genomic context

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    Sequence:
    NC_000913.3 (3648528..3648881)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene arsenite/antimonite:H(+) antiporter Neighboring gene arsenate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Convergent evolution of a new arsenic binding site in the ArsR/SmtB family of metalloregulators. Qin J, et al. J Biol Chem, 2007 Nov 23. PMID 17897948, Free PMC Article
    2. Enhanced arsenic accumulation in engineered bacterial cells expressing ArsR. Kostal J, et al. Appl Environ Microbiol, 2004 Aug. PMID 15294789, Free PMC Article
    3. The role of arsenic-thiol interactions in metalloregulation of the ars operon. Shi W, et al. J Biol Chem, 1996 Apr 19. PMID 8621591
    4. Identification of a putative metal binding site in a new family of metalloregulatory proteins. Shi W, et al. J Biol Chem, 1994 Aug 5. PMID 8051064
    5. The ars operon of Escherichia coli confers arsenical and antimonial resistance. Carlin A, et al. J Bacteriol, 1995 Feb. PMID 7860609, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to arsenic-containing substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to arsenic-containing substance IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor ArsR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3648528..3648881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417958.1 DNA-binding transcriptional repressor ArsR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417958.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0IPV7
      Conserved Domains (1) summary
      PRK10141
      Location:1 → 117
      PRK10141; DNA-binding transcriptional repressor ArsR; Provisional
    Nucleotide Protein
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