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    mdtE multidrug efflux pump membrane fusion protein MdtE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948031, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mdtE
    Official Full Name
    multidrug efflux pump membrane fusion protein MdtE
    Primary source
    ECOCYC:EG12240
    Locus tag
    b3513
    See related
    ASAP:ABE-0011478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3497; yhiU
    Summary
    EvgAS regulon. [More information is available at EcoGene: EG12240]. MdtE has similarity to AcrA, but production of MdtE does not suppress an acrA mutant defect in efflux function with AcrB . [More information is available at EcoCyc: EG12240].
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    Genomic context

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    Sequence:
    NC_000913.3 (3659232..3660389)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator GadE Neighboring gene ncRNA Neighboring gene multidrug efflux pump RND permease MdtF Neighboring gene DNA-binding transcriptional dual regulator GadW

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12. Schaffner SH, et al. Appl Environ Microbiol, 2021 Jul 27. PMID 34085861, Free PMC Article
    2. Role of the AraC-XylS family regulator YdeO in multi-drug resistance of Escherichia coli. Nishino K, et al. J Antibiot (Tokyo), 2009 May. PMID 19329985
    3. Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to beta-lactams. Nishino K, et al. Antimicrob Agents Chemother, 2003 Sep. PMID 12937021, Free PMC Article
    4. CRP regulator modulates multidrug resistance of Escherichia coli by repressing the mdtEF multidrug efflux genes. Nishino K, et al. J Antibiot (Tokyo), 2008 Mar. PMID 18503189
    5. Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli. Zgurskaya HI, et al. J Bacteriol, 2000 Aug. PMID 10894736, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
      Title: Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
    2. GadX increases multidrug resistance in E. coli through activation of the MdtEF efflux pump.
      Title: The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to antibiotic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multidrug efflux pump membrane fusion protein MdtE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3659232..3660389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417970.1 multidrug efflux pump membrane fusion protein MdtE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417970.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A023KQI0, A0A0F3T6A4, A0A1X3HZY0, A0A241QKQ9, A0A377C8T4, A0A4P8BUN5, A0A6G4PAN8, A0A7H9S4E8, A0A7U9QFS2, A0A8S7CSL2, A0A8S7X5G2, A0A9Q6V327, A0AA35F7T6, A0AAD2NU30, A0AAD2YSY5, A0AAN3V8E6, A0AAX2TB00, B7NEF6, C3SNQ7, D3H0W2
      Conserved Domains (1) summary
      PRK09859
      Location:1 → 385
      PRK09859; multidrug transporter subunit MdtE
    Nucleotide Protein
    Heading Accession and Version

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