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    secE Sec translocon subunit SecE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948486, updated on 17-Dec-2024

    Summary

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    Official Symbol
    secE
    Official Full Name
    Sec translocon subunit SecE
    Primary source
    ECOCYC:EG10939
    Locus tag
    b3981
    See related
    ASAP:ABE-0013023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3972; mbrC; prlG
    Summary
    SecYEG complex interacts with SecDFyajC to form a hexameric holocomplex. mbrC17 is a point mutation 23 nt before secE that increases secE and nusB expression. [More information is available at EcoGene: EG10939]. SecE is an inner membrane protein involved in the Sec secretion pathway. [More information is available at EcoCyc: EG10939].
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    Genomic context

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    Sequence:
    NC_000913.3 (4177358..4177741)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene translation elongation factor Tu 2 Neighboring gene transcription termination/antitermination factor NusG Neighboring gene 50S ribosomal subunit protein L11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subunit dynamics in Escherichia coli preprotein translocase. Joly JC, et al. Proc Natl Acad Sci U S A, 1994 May 24. PMID 8197122, Free PMC Article
    2. Nearest neighbor analysis of the SecYEG complex. 2. Identification of a SecY-SecE cytosolic interface. Satoh Y, et al. Biochemistry, 2003 Jun 24. PMID 12809500
    3. New suppressors of signal-sequence mutations, prlG, are linked tightly to the secE gene of Escherichia coli. Stader J, et al. Genes Dev, 1989 Jul. PMID 2673921
    4. One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery. Schatz PJ, et al. EMBO J, 1991 Jul. PMID 2050112, Free PMC Article
    5. A double counter-selection system for the study of null alleles of essential genes in Escherichia coli. Murphy CK, et al. Gene, 1995 Mar 21. PMID 7698651

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
      Title: Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
    2. SecA gains access to the SecYEG complex via a lipid-bound intermediate state, whereas acidic phospholipids allosterically activate SecA for ATP-dependent protein translocation.
      Title: Lipids Activate SecA for High Affinity Binding to the SecYEG Complex.
    3. Authors show that SecG plays a critical role for the residual export mediated by mutant signal sequences and that the SecYE dimer can often be detected only in the presence of SecG.
      Title: Escherichia coli SecG is required for residual export mediated by mutant signal sequences and for SecY-SecE complex stability.
    4. Data suggest that YidC, SecE, and SecA are involved in membrane insertion of M13 procoat lep protein.
      Title: Polarity and charge of the periplasmic loop determine the YidC and sec translocase requirement for the M13 procoat lep protein.
    5. The hydrophobicity threshold for SecYEG-mediated cell membrane insertion is distinctly lower than that for Sec61-mediated insertion.
      Title: Quantitative analysis of SecYEG-mediated insertion of transmembrane α-helices into the bacterial inner membrane.
    6. Data show that ribosome binding is sufficient to open the SecYEG channel.
      Title: The bacterial translocon SecYEG opens upon ribosome binding.
    7. Data indicate taht SecG inversion occurs only when MPIase associates with SecYEG.
      Title: Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation.
    8. Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli
      Title: Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli.
    9. The observed conformational changes thus position SecA for productive interaction with the SecYEG translocon and for transfer of segments of its passenger protein across the translocon
      Title: Using a low denaturant model to explore the conformational features of translocation-active SecA.
    10. SecA can promote protein translocation and ion channel activities both when it is bound to lipids at low affinity sites and when it is bound to SecYEG with high affinity.
      Title: SecA alone can promote protein translocation and ion channel activity: SecYEG increases efficiency and signal peptide specificity.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein insertion into membrane from inner side IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into membrane from inner side IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport by the Sec complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport by the Sec complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport by the Sec complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport by the Sec complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cell envelope Sec protein transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cell envelope Sec protein transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sec translocon subunit SecE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4177358..4177741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418408.1 Sec translocon subunit SecE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418408.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AM75
      Conserved Domains (1) summary
      PRK05740
      Location:33 → 124
      secE; preprotein translocase subunit SecE; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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