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    rplA 50S ribosomal subunit protein L1 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948483, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rplA
    Official Full Name
    50S ribosomal subunit protein L1
    Primary source
    ECOCYC:EG10864
    Locus tag
    b3984
    See related
    ASAP:ABE-0013031
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3975; rpy
    Summary
    The L1 protein is a component of the 50S subunit of the ribosome and also functions in the post-transcriptional regulation of the ribosomal protein genes encoded in the L11 operon. [More information is available at EcoCyc: EG10864].
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    Genomic context

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    Sequence:
    NC_000913.3 (4178879..4179583)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcription termination/antitermination factor NusG Neighboring gene 50S ribosomal subunit protein L11 Neighboring gene 50S ribosomal subunit protein L10 Neighboring gene 50S ribosomal subunit protein L12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific binding of a prokaryotic ribosomal protein to a eukaryotic ribosomal RNA: implications for evolution and autoregulation. Gourse RL, et al. Proc Natl Acad Sci U S A, 1981 May. PMID 6265904, Free PMC Article
    2. Regulation of synthesis of Escherichia coli ribosomal proteins L1 and L11. Brot N, et al. Arch Biochem Biophys, 1981 Jan. PMID 7011209
    3. Functional studies on ribosomes lacking protein L1 from mutant Escherichia coli. Subramanian AR, et al. Eur J Biochem, 1980 Nov. PMID 7007045
    4. Translational regulation of the L11 ribosomal protein operon of Escherichia coli: analysis of the mRNA target site using oligonucleotide-directed mutagenesis. Baughman G, et al. Proc Natl Acad Sci U S A, 1984 Sep. PMID 6382263, Free PMC Article
    5. Localization of the target site for translational regulation of the L11 operon and direct evidence for translational coupling in Escherichia coli. Baughman G, et al. Cell, 1983 Oct. PMID 6354472

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    50S ribosomal subunit protein L1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4178879..4179583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418411.1 50S ribosomal subunit protein L1 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418411.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AMZ5
      Conserved Domains (1) summary
      PRK05424
      Location:2 → 231
      rplA; 50S ribosomal protein L1; Validated
    Nucleotide Protein
    Heading Accession and Version

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