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    cycA D-serine/alanine/glycine/:H(+)symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948725, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cycA
    Official Full Name
    D-serine/alanine/glycine/:H(+)symporter
    Primary source
    ECOCYC:EG12504
    Locus tag
    b4208
    See related
    ASAP:ABE-0013764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dagA; ECK4204; ytfD
    Summary
    CycA is a transporter involved in the uptake of glycine, serine and alanine. [More information is available at EcoCyc: EG12504].
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    Genomic context

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    Sequence:
    NC_000913.3 (4429864..4431276)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene cell division protein YtfB Neighboring gene peptidyl-prolyl cis-trans isomerase FklB Neighboring gene iron-sulfur cluster repair protein YtfE Neighboring gene inner membrane protein YtfF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli. Shi H, et al. Microbiol Spectr, 2022 Dec 21. PMID 36377953, Free PMC Article
    2. Transport systems for alanine, serine, and glycine in Escherichia coli K-12. Robbins JC, et al. J Bacteriol, 1973 Oct. PMID 4583203, Free PMC Article
    3. Mechanism of D-cycloserine action: transport mutants for D-alanine, D-cycloserine, and glycine. Wargel RJ, et al. J Bacteriol, 1971 Mar. PMID 4926674, Free PMC Article
    4. Identification and characterization of the main beta-alanine uptake system in Escherichia coli. Schneider F, et al. Appl Microbiol Biotechnol, 2004 Oct. PMID 15221223
    5. Characterization of cycA mutants of Escherichia coli. An assay for measuring in vivo mutation rates. Fehér T, et al. Mutat Res, 2006 Mar 20. PMID 16376388

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli.
      Title: CycA-Dependent Glycine Assimilation Is Connected to Novobiocin Susceptibility in Escherichia coli.
    2. beta-Alanine uptake was found to be an active process catalyzed by the amino acid carrier CycA.
      Title: Identification and characterization of the main beta-alanine uptake system in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-alanine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables D-serine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-alanine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables beta-alanine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-alanine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within D-serine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within L-alanine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within beta-alanine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-serine/alanine/glycine/:H(+)symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4429864..4431276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418629.1 D-serine/alanine/glycine/:H(+)symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418629.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3P5DKG1
      Conserved Domains (1) summary
      PRK11049
      Location:2 → 470
      PRK11049; D-alanine/D-serine/glycine permease; Provisional
    Nucleotide Protein
    Heading Accession and Version

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