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    yjjG pyrimidine 5'-nucleotidase YjjG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948899, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yjjG
    Official Full Name
    pyrimidine 5'-nucleotidase YjjG
    Primary source
    ECOCYC:EG12115
    Locus tag
    b4374
    See related
    ASAP:ABE-0014344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4365
    Summary
    Efficient in vitro substrates include: dUMP, UMP, and dTMP; phosphoramidase: in vitro activities demonstrated by Kuznetsova et al. [More information is available at EcoGene: EG12115]. YjjG is a monophosphatase whose activity is essential for thymine salvage in a thyA (|FRAME: [More information is available at EcoCyc: EG12115].
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    Genomic context

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    Sequence:
    NC_000913.3 (4608646..4609323)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(2)G1207 methyltransferase Neighboring gene DNA polymerase III subunit psi Neighboring gene protein N-acetyltransferase RimI Neighboring gene peptide chain release factor RF3 Neighboring gene periplasmic chaperone OsmY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12. Weiss B. J Bacteriol, 2007 Mar. PMID 17189366, Free PMC Article
    2. A deoxyuridine monophosphate phosphatase detected in mutants of Escherichia coli lacking alkaline phosphatase and 5'-nucleotidase. Uerkvitz W, et al. Mol Gen Genet, 1973 Mar 19. PMID 4571806
    3. The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains. Itsko M, et al. Mol Microbiol, 2011 Sep. PMID 21736641, Free PMC Article
    4. Multiple stressor-induced proteome responses of Escherichia coli BL21(DE3). Han KY, et al. J Proteome Res, 2008 May. PMID 18363324
    5. Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Burland V, et al. Nucleic Acids Res, 1995 Jun 25. PMID 7610040, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blockage of the yjjG pathway for deoxyribose-1-phosphate generation greatly exacerbated the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death.
      Title: The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains.
    2. YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.
      Title: YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.
    3. identified the presence of nucleotidase activity in three uncharacterized E. coli proteins, SurE, YfbR, and YjjG, that belong to different enzyme superfamilies
      Title: General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG.
    4. The substrate spectrum of YjjG suggests that its in vivo substrates are noncanonical pyrimidine derivatives, which might also include oxidized nucleobases such as 5-formyluracil and 5-hydroxyuracil.
      Title: The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5'-deoxynucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables XMP 5'-nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidylate 5'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pyrimidine nucleobase salvage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pyrimidine ribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thymine metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyrimidine 5'-nucleotidase YjjG
    NP_418791.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4608646..4609323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418791.1 pyrimidine 5'-nucleotidase YjjG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418791.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CVR0
      Conserved Domains (1) summary
      PRK09449
      Location:1 → 224
      PRK09449; dUMP phosphatase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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