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    djlA co-chaperone protein DjlA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948992, updated on 17-Dec-2024

    Summary

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    Official Symbol
    djlA
    Official Full Name
    co-chaperone protein DjlA
    Primary source
    ECOCYC:EG11570
    Locus tag
    b0055
    See related
    ASAP:ABE-0000187
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0056; yabH
    Summary
    DjlA overproduction activates RcsBC and Cps synthesis and causes mucoidy. [More information is available at EcoGene: EG11570]. DjlA functions as a co-chaperone with DnaK and is involved in the regulation of the synthesis of the colanic acid capsule. [More information is available at EcoCyc: EG11570].
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    Genomic context

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    Sequence:
    NC_000913.3 (57364..58179)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 4-hydroxythreonine-4-phosphate dehydrogenase Neighboring gene chaperone SurA Neighboring gene lipopolysaccharide assembly protein LptD Neighboring gene putative uncharacterized protein YabP Neighboring gene protein YabQ Neighboring gene 23S rRNA pseudouridine(746) and tRNA pseudouridine(32) synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Point mutations in the transmembrane domain of DjlA, a membrane-linked DnaJ-like protein, abolish its function in promoting colanic acid production via the Rcs signal transduction pathway. Clarke DJ, et al. Mol Microbiol, 1997 Sep. PMID 9364918
    2. Increased sensitivity of E. coli to novobiocin, EDTA and the anticalmodulin drug W7 following overproduction of DjlA requires a functional transmembrane domain. Bernard S, et al. Mol Gen Genet, 1998 Oct. PMID 9819058
    3. The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth. Genevaux P, et al. J Bacteriol, 2001 Oct. PMID 11544239, Free PMC Article
    4. Rates of DNA sequence evolution in experimental populations of Escherichia coli during 20,000 generations. Lenski RE, et al. J Mol Evol, 2003 Apr. PMID 12664169
    5. All three J-domain proteins of the Escherichia coli DnaK chaperone machinery are DNA binding proteins. Gur E, et al. FEBS Lett, 2005 Mar 28. PMID 15792799

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In a DnaJ mutant both CbpA and DjlA are required for efficient DnaK mediated protein dissaggregation at 42 degrees C.
      Title: The Escherichia coli DjlA and CbpA proteins can substitute for DnaJ in DnaK-mediated protein disaggregation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    co-chaperone protein DjlA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      57364..58179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414597.1 co-chaperone protein DjlA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414597.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GCD9
      Conserved Domains (1) summary
      PRK09430
      Location:1 → 271
      djlA; co-chaperone DjlA
    Nucleotide Protein
    Heading Accession and Version

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