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    lpd lipoamide dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944854, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lpd
    Official Full Name
    lipoamide dehydrogenase
    Primary source
    ECOCYC:EG10543
    Locus tag
    b0116
    See related
    ASAP:ABE-0000404
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dhl; ECK0115; lpdA
    Summary
    Holoenzyme is AceE(24)+AceF(24)+Lpd(12). [More information is available at EcoGene: EG10543]. Lipoamide dehydrogenase is the E3 component of three multicomponent enzyme complexes: |FRAME: [More information is available at EcoCyc: EG10543].
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    Genomic context

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    Sequence:
    NC_000913.3 (127912..129336)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase E1 component Neighboring gene pyruvate dehydrogenase, E2 subunit Neighboring gene DUF3300 domain-containing protein YacH Neighboring gene AcnB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipoamide dehydrogenase from Escherichia coli lacking the redox active disulfide: C44S and C49S. Redox properties of the FAD and interactions with pyridine nucleotides. Hopkins N, et al. Biochemistry, 1995 Sep 19. PMID 7547909
    2. alpha-Keto acid dehydrogenation complexes. IV. Resolution and reconstitution of the Escherichia coli pyruvate dehydrogenation complex. KOIKE M, et al. J Biol Chem, 1963 Jan. PMID 14034257
    3. Lipoamide dehydrogenase from Escherichia coli. Steady-state kinetics of the physiological reaction. Sahlman L, et al. J Biol Chem, 1989 May 15. PMID 2498307
    4. Purification of a new dihydrolipoamide dehydrogenase from Escherichia coli. Richarme G. J Bacteriol, 1989 Dec. PMID 2687245, Free PMC Article
    5. FAD insertion is essential for attaining the assembly competence of the dihydrolipoamide dehydrogenase (E3) monomer from Escherichia coli. Lindsay H, et al. J Biol Chem, 2000 Nov 24. PMID 10970889

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex.
      Title: Dimerization of a 5-kDa domain defines the architecture of the 5-MDa gammaproteobacterial pyruvate dehydrogenase complex.
    2. Glutamate at position 354 plays a structural role in establishing the NADH sensitivity of LPD and the PDH complex by lowering the affinity for NADH.
      Title: Amino acid substitutions at glutamate-354 in dihydrolipoamide dehydrogenase of Escherichia coli lower the sensitivity of pyruvate dehydrogenase to NADH.
    3. results show that a mutation in LPD led to a pyruvate dehydrogenase complex that is less sensitive to inhibition by NADH
      Title: Dihydrolipoamide dehydrogenase mutation alters the NADH sensitivity of pyruvate dehydrogenase complex of Escherichia coli K-12.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    lipoamide dehydrogenase
    NP_414658.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      127912..129336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414658.1 lipoamide dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414658.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2YWK3
      Conserved Domains (1) summary
      PRK06467
      Location:3 → 472
      PRK06467; dihydrolipoamide dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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