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    ampG muropeptide:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946438, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ampG
    Official Full Name
    muropeptide:H(+) symporter
    Primary source
    ECOCYC:EG12183
    Locus tag
    b0433
    See related
    ASAP:ABE-0001501
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0427
    Summary
    Imported muropeptides must contain the disaccharide GlcNAc-anhMurNAc, which is also efficiently transported without attached peptides. [More information is available at EcoGene: EG12183]. AmpG is a member of the major facilitator superfamily of transporters, and together with AmpD, is essential for induction of the AmpC -lactamase and is involved in the recycling of cell wall peptides . [More information is available at EcoCyc: EG12183].
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    Genomic context

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    Sequence:
    NC_000913.3 (452070..453545, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bo3 subunit 3 Neighboring gene cytochrome bo3 subunit 1 Neighboring gene cytochrome bo3 subunit 2 Neighboring gene putative lipoprotein YajG Neighboring gene DNA-binding transcriptional dual regulator BolA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of beta-lactamase in Enterobacter cloacae. Wiedemann B, et al. Clin Infect Dis, 1998 Aug. PMID 9710670
    2. ampG is essential for high-level expression of AmpC beta-lactamase in Enterobacter cloacae. Korfmann G, et al. Antimicrob Agents Chemother, 1989 Nov. PMID 2692514, Free PMC Article
    3. The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers. Schmidt H, et al. Microbiology (Reading), 1995 May. PMID 7773404
    4. AmpD, essential for both beta-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-L-alanine amidase. Jacobs C, et al. Mol Microbiol, 1995 Feb. PMID 7783625
    5. beta-Lactamase induction in gram-negative bacteria is intimately linked to peptidoglycan recycling. Normark S. Microb Drug Resist, 1995 Summer. PMID 9158742

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of AmpG permease decrease in the biofilm-forming ability.
      Title: Involvement of AmpG in mediating a dynamic relationship between serine beta-lactamase induction and biofilm-forming ability of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables peptidoglycan transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan turnover IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    muropeptide:H(+) symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      452070..453545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414967.1 muropeptide:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414967.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A3C163
      Conserved Domains (1) summary
      PRK11010
      Location:1 → 490
      ampG; muropeptide MFS transporter AmpG
    Nucleotide Protein
    Heading Accession and Version

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