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    ybiO moderate conductance mechanosensitive channel YbiO [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945935, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ybiO
    Official Full Name
    moderate conductance mechanosensitive channel YbiO
    Primary source
    ECOCYC:G6417
    Locus tag
    b0808
    See related
    ASAP:ABE-0002760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0797
    Summary
    mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs. [More information is available at EcoGene: EG13320]. YbiO exhibits sequence homology to the small mechanosensitive ion channel (MscS) however YbiO deletion mutants exhibit no detectable phenotype and its function remains unknown . [More information is available at EcoCyc: G6417].
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    Genomic context

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    Sequence:
    NC_000913.3 (843255..845480, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene iron catecholate outer membrane transporter Fiu Neighboring gene DUF1471 domain-containing protein McbA Neighboring gene 23S rRNA m(6)A1618 methyltransferase Neighboring gene L-glutamine ABC transporter ATP binding subunit Neighboring gene L-glutamine ABC transporter membrane subunit Neighboring gene L-glutamine ABC transporter periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MscS-like channel YnaI has a gating mechanism based on flexible pore helices. Flegler VJ, et al. Proc Natl Acad Sci U S A, 2020 Nov 17. PMID 33148804, Free PMC Article
    2. Analysis of the kefA2 mutation suggests that KefA is a cation-specific channel involved in osmotic adaptation in Escherichia coli. McLaggan D, et al. Mol Microbiol, 2002 Jan. PMID 11985727
    3. Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity. Levina N, et al. EMBO J, 1999 Apr 1. PMID 10202137, Free PMC Article
    4. Identification of conserved, RpoS-dependent stationary-phase genes of Escherichia coli. Schellhorn HE, et al. J Bacteriol, 1998 Dec. PMID 9829938, Free PMC Article
    5. Characterization of three novel mechanosensitive channel activities in Escherichia coli. Edwards MD, et al. Channels (Austin), 2012 Jul-Aug. PMID 22874652, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
      Title: The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
    2. High level expression of YbiO proteins from a multicopy plasmid in the Delta7 strain (MJFGH) leads to substantial protection against hypoosmotic shock.
      Title: Characterization of three novel mechanosensitive channel activities in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to osmotic stress EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    moderate conductance mechanosensitive channel YbiO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      843255..845480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415329.4 moderate conductance mechanosensitive channel YbiO [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415329.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BMW9
      Conserved Domains (1) summary
      PRK11465
      Location:1 → 741
      PRK11465; putative mechanosensitive channel protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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