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    fabI enoyl-[acyl-carrier-protein] reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945870, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fabI
    Official Full Name
    enoyl-[acyl-carrier-protein] reductase
    Primary source
    ECOCYC:EG11528
    Locus tag
    b1288
    See related
    ASAP:ABE-0004327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1283; envM; gts; qmeA
    Summary
    fabI is an essential gene. [More information is available at EcoGene: EG11528]. The FabI protein is an enoyl acyl carrier protein reductase which catalyzes an essential step in fatty acid biosynthesis. [More information is available at EcoCyc: EG11528].
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    Genomic context

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    Sequence:
    NC_000913.3 (1350251..1351039, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNase II Neighboring gene putative peroxidase YciW Neighboring gene DUF559 domain-containing protein YcjD Neighboring gene putrescine ABC exporter ATP binding protein SapF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular genetic analysis of enoyl-acyl carrier protein reductase inhibition by diazaborine. de Boer GJ, et al. Mol Microbiol, 1999 Jan. PMID 10027962
    2. Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance. Protasevich II, et al. Biochemistry, 2004 Oct 26. PMID 15491144
    3. Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase. Ling LL, et al. Antimicrob Agents Chemother, 2004 May. PMID 15105103, Free PMC Article
    4. Similarities and differences in genome-wide expression data of six organisms. Bergmann S, et al. PLoS Biol, 2004 Jan. PMID 14737187, Free PMC Article
    5. Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues. Sivaraman S, et al. J Med Chem, 2004 Jan 29. PMID 14736233

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The prevalence and mechanism of triclosan resistance in Escherichia coli isolated from urine samples in Wenzhou, China.
      Title: The prevalence and mechanism of triclosan resistance in Escherichia coli isolated from urine samples in Wenzhou, China.
    2. Effects of lysine 2-hydroxyisobutyrylation on bacterial FabI activity and resistance to triclosan.
      Title: Effects of lysine 2-hydroxyisobutyrylation on bacterial FabI activity and resistance to triclosan.
    3. Reduced susceptibility to antiseptics is conferred by heterologous housekeeping genes, fabI and gale.
      Title: Reduced Susceptibility to Antiseptics Is Conferred by Heterologous Housekeeping Genes.
    4. FabI encodes a native enoyl-CoA reductase activity that supports the beta-oxidation reversal in E. coli.
      Title: Escherichia coli enoyl-acyl carrier protein reductase (FabI) supports efficient operation of a functional reversal of β-oxidation cycle.
    5. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    6. crystallographic analysis of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli
      Title: Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADH binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enoyl-[acyl-carrier-protein] reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enoyl-[acyl-carrier-protein] reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enoyl-[acyl-carrier-protein] reductase
    NP_415804.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1350251..1351039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415804.1 enoyl-[acyl-carrier-protein] reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415804.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DUN4
      Conserved Domains (1) summary
      PRK07984
      Location:1 → 262
      PRK07984; enoyl-ACP reductase FabI
    Nucleotide Protein
    Heading Accession and Version

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