U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    purR DNA-binding transcriptional repressor PurR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945226, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    purR
    Official Full Name
    DNA-binding transcriptional repressor PurR
    Primary source
    ECOCYC:EG10800
    Locus tag
    b1658
    See related
    ASAP:ABE-0005545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1654
    Summary
    The purine regulon includes purBCDEFHKLMN and guaBA. [More information is available at EcoGene: EG10800]. PurR is a protein that belongs to the GalR/LacI family. [More information is available at EcoCyc: EG10800].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1737844..1738869)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YdhP Neighboring gene cytochrome bd-I accessory subunit CydH Neighboring gene DNA-binding transcriptional activator PunR Neighboring gene purine nucleoside transporter PunC Neighboring gene cyclopropane fatty acyl phospholipid synthase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role of the purine repressor hinge sequence in repressor function. Choi KY, et al. J Bacteriol, 1994 Mar. PMID 8132474, Free PMC Article
    2. The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. Glasfeld A, et al. J Mol Biol, 1999 Aug 13. PMID 10438625
    3. Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling. Lu F, et al. Biochemistry, 1998 Nov 10. PMID 9843372
    4. The structure of PurR mutant L54M shows an alternative route to DNA kinking. Arvidson DN, et al. Nat Struct Biol, 1998 Jun. PMID 9628480
    5. Kinetic and thermodynamic studies of purine repressor binding to corepressor and operator DNA. Xu H, et al. J Biol Chem, 1998 Apr 10. PMID 9535880

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional repressor PurR

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1737844..1738869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416175.1 DNA-binding transcriptional repressor PurR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416175.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN4NUG0
      Conserved Domains (1) summary
      PRK10703
      Location:1 → 341
      PRK10703; HTH-type transcriptional repressor PurR
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials