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    dgcQ diguanylate cyclase DgcQ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946471, updated on 3-Dec-2024

    Summary

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    Official Symbol
    dgcQ
    Official Full Name
    diguanylate cyclase DgcQ
    Primary source
    ECOCYC:G7049
    Locus tag
    b1956
    See related
    ASAP:ABE-0006495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1954; yedQ
    Summary
    A null ydeQ mutation slightly suppresses the motility defect of a yhjH null mutant at 28C and 37C; a yedQ mutation is needed in addition to yegE (28C) or yegE yeaJ (37) to restore full motility to the yhjH mutant (Pesavento, 2008).YedQ has a C-terminal GGDEF domain. [More information is available at EcoGene: EG14040]. Expression of yedQ is dependent on S under a number of stress conditions. [More information is available at EcoCyc: G7049].
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    Genomic context

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    Sequence:
    NC_000913.3 (2026323..2028017, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stress-induced protein Neighboring gene ncRNA Neighboring gene putative mannosyl-3-phosphoglycerate phosphatase Neighboring gene protein YodC Neighboring gene DUF808 domain-containing inner membrane protein YedI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli. Kim HA, et al. Microb Cell Fact, 2017 Jun 15. PMID 28619035, Free PMC Article
    2. GGDEF proteins YeaI, YedQ, and YfiN reduce early biofilm formation and swimming motility in Escherichia coli. Sanchez-Torres V, et al. Appl Microbiol Biotechnol, 2011 Apr. PMID 21181144, Free PMC Article
    3. Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli. Weber H, et al. Mol Microbiol, 2006 Nov. PMID 17010156
    4. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
    5. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DgcQ (YedQ) diguanylate cyclase enzymatic activity is enhanced by Uridine Triphosphate, whilst being inhibited by N-carbamoyl-aspartate, an intermediate of the de novo pathway.
      Title: Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c-di-GMP production by the DgcQ protein of Escherichia coli.
    2. YeaI, YedQ, and YfiN are active diguanylate cyclases that reduce motility, eDNA, and early biofilm formation.
      Title: GGDEF proteins YeaI, YedQ, and YfiN reduce early biofilm formation and swimming motility in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables diguanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diguanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellulose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diguanylate cyclase DgcQ
    NP_416465.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2026323..2028017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416465.2 diguanylate cyclase DgcQ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416465.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7L7E8I6
      Conserved Domains (1) summary
      PRK15426
      Location:1 → 564
      PRK15426; cellulose biosynthesis regulator YedQ
    Nucleotide Protein
    Heading Accession and Version

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