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    ccmC cytochrome c maturation protein C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946703, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ccmC
    Official Full Name
    cytochrome c maturation protein C
    Primary source
    ECOCYC:EG12057
    Locus tag
    b2199
    See related
    ASAP:ABE-0007275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2191; yejT; yejU
    Summary
    CcmC is an integral membrane component of the CcmABC protoheme IX ABC transporter. [More information is available at EcoCyc: EG12057].
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    Genomic context

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    Sequence:
    NC_000913.3 (2295583..2296320, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene holocytochrome c synthase CcmH component Neighboring gene thiol:disulfide oxidoreductase CcmG Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein B Neighboring gene cytochrome c maturation protein A Neighboring gene periplasmic nitrate reductase cytochrome c protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CcmC:heme:CcmE complex in heme trafficking and cytochrome c biosynthesis. Richard-Fogal C, et al. J Mol Biol, 2010 Aug 20. PMID 20599545, Free PMC Article
    2. Dynamic features of a heme delivery system for cytochrome C maturation. Ahuja U, et al. J Biol Chem, 2003 Dec 26. PMID 14532274
    3. Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Lee JH, et al. Biochim Biophys Acta, 2007 Sep. PMID 17706591
    4. Physical interaction of CcmC with heme and the heme chaperone CcmE during cytochrome c maturation. Ren Q, et al. J Biol Chem, 2001 Aug 31. PMID 11384983
    5. Probing heme delivery processes in cytochrome c biogenesis System I. Mavridou DA, et al. Biochemistry, 2013 Oct 15. PMID 24044352, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytochrome c biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytochrome complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytochrome complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c maturation protein C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2295583..2296320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416703.1 cytochrome c maturation protein C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416703.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5D8MXA3, A0A8T5YAP0
      Conserved Domains (1) summary
      TIGR01191
      Location:45 → 225
      ccmC; heme exporter protein CcmC
    Nucleotide Protein
    Heading Accession and Version

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