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    amiC N-acetylmuramoyl-L-alanine amidase C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947293, updated on 3-Dec-2024

    Summary

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    Official Symbol
    amiC
    Official Full Name
    N-acetylmuramoyl-L-alanine amidase C
    Primary source
    ECOCYC:G7458
    Locus tag
    b2817
    See related
    ASAP:ABE-0009238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2813; ygdN
    Summary
    Verified Tat substrate: [More information is available at EcoGene: EG13086]. AmiC is an N-acetylmuramyl-L-alanine amidase, which cleaves the peptide moiety from N-acetylmuramic acid, removing murein crosslinks. [More information is available at EcoCyc: G7458].
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    Genomic context

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    Sequence:
    NC_000913.3 (2947757..2949010, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene tRNA-Met Neighboring gene N-acetylglutamate synthase Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antitermination of amidase expression in Pseudomonas aeruginosa is controlled by a novel cytoplasmic amide-binding protein. Wilson SA, et al. EMBO J, 1993 Sep. PMID 8253087, Free PMC Article
    2. Oligomerization of the amide sensor protein AmiC by x-ray and neutron scattering and molecular modeling. Chamberlain D, et al. Biochemistry, 1997 Jul 1. PMID 9201949
    3. Proteolytic processing of Escherichia coli twin-arginine signal peptides by LepB. Lüke I, et al. Arch Microbiol, 2009 Dec. PMID 19809807
    4. Visualization of proteins in intact cells with a clonable tag for electron microscopy. Diestra E, et al. J Struct Biol, 2009 Mar. PMID 19114107
    5. Activity of three murein hydrolases during the cell division cycle of Escherichia coli K-12 as measured in toluene-treated cells. Beck BD, et al. J Bacteriol, 1976 Jun. PMID 780345, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
      Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylmuramoyl-L-alanine amidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylmuramoyl-L-alanine amidase C
    NP_417294.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2947757..2949010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417294.4 N-acetylmuramoyl-L-alanine amidase C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417294.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9K280
      Conserved Domains (2) summary
      PRK10319
      Location:171 → 409
      PRK10319; N-acetylmuramoyl-L-alanine amidase AmiA
      pfam11741
      Location:39 → 142
      AMIN; AMIN domain
    Nucleotide Protein
    Heading Accession and Version

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