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    yggX putative Fe(2(+))-trafficking protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947461, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yggX
    Official Full Name
    putative Fe(2(+))-trafficking protein
    Primary source
    ECOCYC:G7532
    Locus tag
    b2962
    See related
    ASAP:ABE-0009722
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2957
    Summary
    SoxRS regulon. [More information is available at EcoGene: EG12984]. YggX is proposed to play a role in oxidation-resistance of iron-sulfur clusters . [More information is available at EcoCyc: G7532].
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    Genomic context

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    Sequence:
    NC_000913.3 (3104093..3104368)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative ribosome assembly factor YggL Neighboring gene tRNA m(7)G46 methyltransferase Neighboring gene adenine DNA glycosylase Neighboring gene membrane-bound lytic murein transglycosylase C Neighboring gene nucleoside:H(+) symporter NupG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica. Gralnick J, et al. Proc Natl Acad Sci U S A, 2001 Jul 3. PMID 11416172, Free PMC Article
    2. The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. Gralnick JA, et al. J Biol Chem, 2003 Jun 6. PMID 12670952
    3. Solution structure of YggX: a prokaryotic protein involved in Fe(II) trafficking. Cui Q, et al. Proteins, 2006 Mar 15. PMID 16329120
    4. Oxidative stress and disruption of labile iron generate specific auxotrophic requirements in Salmonella enterica. Thorgersen MP, et al. Microbiology (Reading), 2009 Jan. PMID 19118370, Free PMC Article
    5. Lack of YggX results in chronic oxidative stress and uncovers subtle defects in Fe-S cluster metabolism in Salmonella enterica. Skovran E, et al. J Bacteriol, 2004 Nov. PMID 15516576, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Small genes/gene-products in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative Fe(2(+))-trafficking protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3104093..3104368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417437.1 putative Fe(2(+))-trafficking protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417437.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376VD81
      Conserved Domains (1) summary
      COG2924
      Location:1 → 90
      YggX; Fe-S cluster biosynthesis and repair protein YggX [Inorganic ion transport and metabolism, Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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