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    hybD hydrogenase 2 maturation protease [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948982, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hybD
    Official Full Name
    hydrogenase 2 maturation protease
    Primary source
    ECOCYC:EG11802
    Locus tag
    b2993
    See related
    ASAP:ABE-0009826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2987
    Summary
    Based on its similarity to the processing enzyme for hydrogenase 3, HycI, HybD is predicted to be an endopeptidase involved in the maturation of the large subunit of hydrogenase 2 (HybC) . [More information is available at EcoCyc: EG11802].
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    Genomic context

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    Sequence:
    NC_000913.3 (3140792..3141286, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase maturation factor HybG Neighboring gene hydrogenase maturation protein HybF Neighboring gene hydrogenase 2-specific chaperone Neighboring gene hydrogenase 2 large subunit Neighboring gene hydrogenase 2 membrane subunit Neighboring gene hydrogenase 2 iron-sulfur protein Neighboring gene hydrogenase 2 small subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Delimiting the Function of the C-Terminal Extension of the Escherichia coli [NiFe]-Hydrogenase 2 Large Subunit Precursor. Pinske C, et al. Front Microbiol, 2019. PMID 31611859, Free PMC Article
    2. Proteolytic cleavage orchestrates cofactor insertion and protein assembly in [NiFe]-hydrogenase biosynthesis. Senger M, et al. J Biol Chem, 2017 Jul 14. PMID 28539366, Free PMC Article
    3. Coordination of Synthesis and Assembly of a Modular Membrane-Associated [NiFe]-Hydrogenase Is Determined by Cleavage of the C-Terminal Peptide. Thomas C, et al. J Bacteriol, 2015 Sep. PMID 26170410, Free PMC Article
    4. Development of a cell-free system reveals an oxygen-labile step in the maturation of [NiFe]-hydrogenase 2 of Escherichia coli. Soboh B, et al. FEBS Lett, 2010 Sep 24. PMID 20807532
    5. Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation. Theodoratou E, et al. Eur J Biochem, 2000 Apr. PMID 10727938

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydrogenase 2 maturation protease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3140792..3141286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417467.1 hydrogenase 2 maturation protease [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417467.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AP02
      Conserved Domains (1) summary
      PRK10466
      Location:1 → 164
      hybD; HyaD/HybD family hydrogenase maturation endopeptidase
    Nucleotide Protein
    Heading Accession and Version

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