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    hybA hydrogenase 2 iron-sulfur protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944842, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hybA
    Official Full Name
    hydrogenase 2 iron-sulfur protein
    Primary source
    ECOCYC:EG11799
    Locus tag
    b2996
    See related
    ASAP:ABE-0009832
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2990; hydL
    Summary
    Upregulated in biofilms; biofilm microarray result was validated with RT-PCR. [More information is available at EcoGene: EG11799]. The hybA-encoded protein may be involved in the periplasmic electron-transferring activity of hydrogenase 2 during catalytic turnover . [More information is available at EcoCyc: EG11799].
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    Genomic context

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    Sequence:
    NC_000913.3 (3144154..3145140, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase maturation protein HybF Neighboring gene hydrogenase 2-specific chaperone Neighboring gene hydrogenase 2 maturation protease Neighboring gene hydrogenase 2 large subunit Neighboring gene hydrogenase 2 membrane subunit Neighboring gene hydrogenase 2 small subunit Neighboring gene DUF2623 domain-containing protein YghW

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Partial characterization of an electrophoretically labile hydrogenase activity of Escherichia coli K-12. Stoker K, et al. J Bacteriol, 1988 Mar. PMID 3277948, Free PMC Article
    2. Isolation and characterization of mutant strains of Escherichia coli altered in H2 metabolism. Lee JH, et al. J Bacteriol, 1985 Apr. PMID 3884594, Free PMC Article
    3. Proton translocation coupled to formate oxidation in anaerobically grown fermenting Escherichia coli. Hakobyan M, et al. Biophys Chem, 2005 May 1. PMID 15848284
    4. Isolation and characterisation of a soluble active fragment of hydrogenase isoenzyme 2 from the membranes of anaerobically grown Escherichia coli. Ballantine SP, et al. Eur J Biochem, 1986 Apr 15. PMID 3516690
    5. Requirement for nickel of the transmembrane translocation of NiFe-hydrogenase 2 in Escherichia coli. Rodrigue A, et al. FEBS Lett, 1996 Aug 26. PMID 8772179

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrogen:quinone oxidoreductase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables iron-sulfur cluster binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anaerobic glycerol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within anaerobic respiration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydrogenase 2 iron-sulfur protein
    NP_417470.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3144154..3145140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417470.1 hydrogenase 2 iron-sulfur protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417470.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GF22
      Conserved Domains (1) summary
      PRK10882
      Location:1 → 328
      PRK10882; hydrogenase 2 operon protein HybA
    Nucleotide Protein
    Heading Accession and Version

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