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    yghB DedA family protein YghB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947490, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yghB
    Official Full Name
    DedA family protein YghB
    Primary source
    ECOCYC:EG11824
    Locus tag
    b3009
    See related
    ASAP:ABE-0009882
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3001
    Summary
    A yqjA yghB double mutant has a membrane defect causing a cell division defect at low temperatures and an osmoremedial growth defect at elevated temperatures (Thomkins, 2008). [More information is available at EcoGene: EG11824]. YghB is a member of the DedA family of inner membrane proteins . [More information is available at EcoCyc: EG11824].
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    Genomic context

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    Sequence:
    NC_000913.3 (3153563..3154222)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Ton complex subunit ExbB Neighboring gene cystathionine beta-lyase/L-cysteine desulfhydrase/alanine racemase Neighboring gene DNA-binding transcriptional activator YqhC Neighboring gene NADPH-dependent aldehyde reductase YqhD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB. Kumar S, et al. FEMS Microbiol Lett, 2016 Jul. PMID 27190159
    2. Transcription factor distribution in Escherichia coli: studies with FNR protein. Grainger DC, et al. Nucleic Acids Res, 2007. PMID 17164287, Free PMC Article
    3. Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region. Belfaiza J, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3513164, Free PMC Article
    4. Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes. Sikdar R, et al. J Bacteriol, 2010 Feb. PMID 19880597, Free PMC Article
    5. DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli. DeLisa MP, et al. J Bacteriol, 2001 Sep. PMID 11514505, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. discovery of 2 conserved predicted membrane-embedded arginines (R130 and R136) that are critical for function in both YqjA and YghB; lysine can substitute for arginine at position R130 indicating a charge dependence at this position, but could not substitute at R136; study provides mechanistic insight into YqjA and YghB and supports the hypothesis that they function as membrane transporters
      Title: Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB.
    2. Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
      Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
    3. Data show that it is likely that yghB play critical roles in membrane biology that are essential for completion of cell division in E. coli.
      Title: Temperature sensitivity and cell division defects in an Escherichia coli strain with mutations in yghB and yqjA, encoding related and conserved inner membrane proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DedA family protein YghB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3153563..3154222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417482.1 DedA family protein YghB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417482.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376ZIL8
      Conserved Domains (1) summary
      COG0586
      Location:24 → 219
      DedA; Uncharacterized membrane protein DedA, SNARE-associated domain [Function unknown]
    Nucleotide Protein
    Heading Accession and Version

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