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    rnpB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947634, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rnpB
    Primary source
    ECOCYC:EG30069
    Locus tag
    b3123
    See related
    ASAP:ABE-0010269
    Gene type
    ncRNA
    RNA name
    other
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3111
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    Genomic context

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    Sequence:
    NC_000913.3 (3270216..3270592, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YhaB Neighboring gene uncharacterized protein YhaC Neighboring gene glycerate 2-kinase 1 Neighboring gene tartronate semialdehyde reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recent approaches to probe functional groups in ribonuclease P RNA by modification interference. Hardt WD, et al. Mol Biol Rep, 1995-1996. PMID 8901505
    2. In vitro selection for altered divalent metal specificity in the RNase P RNA. Frank DN, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405616, Free PMC Article
    3. Phenotypic conversion of drug-resistant bacteria to drug sensitivity. Guerrier-Takada C, et al. Proc Natl Acad Sci U S A, 1997 Aug 5. PMID 9238000, Free PMC Article
    4. Design and preparation of sequence-specific RNase P ribozymes. Drainas D, et al. Methods Mol Biol, 1997. PMID 9204433
    5. Function of the repeated sequence in the 3' flanking region of the Escherichia coli rnpB gene on transcription termination and RNA processing. Kim S, et al. FEBS Lett, 1997 May 5. PMID 9175883

    See all (303) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study provides new insights into the interaction between E. coli RNase P RNA and the -1 residue in the substrate.
      Title: Transition-state stabilization in Escherichia coli ribonuclease P RNA-mediated cleavage of model substrates.
    2. Collectively, these findings emphasize the interplay between separate regions upon formation of a productive RNase P RNA substrate that leads to efficient and accurate cleavage.
      Title: Functional coupling between a distal interaction and the cleavage site in bacterial RNase-P-RNA-mediated cleavage.
    3. P12 and P13 domains of RNase P RNA are necessary for efficient enzymatic reactions.
      Title: Mutational analysis on the S-domain of bacterial ribonuclease P ribozyme.
    4. These results imply that Rnase E plays a dual role in processing and degradation to achieve tight control of M1 RNA biosynthesis.
      Title: Dual function of RNase E for control of M1 RNA biosynthesis in Escherichia coli.
    5. The effects of different metal ions on catalysis by M1 RNA.
      Title: Studies on Escherichia coli RNase P RNA with Zn2+ as the catalytic cofactor.
    6. the 3' processing of M1 RNA provides a functional mechanism for the protection of its primary transcript against degradation
      Title: Processing of m1 RNA at the 3' end protects its primary transcript from degradation.
    7. A single base mutation in RNase P RNA changes its function through changes of the metal ion binding site.
      Title: Change of RNase P RNA function by single base mutation correlates with perturbation of metal ion binding in P4 as determined by NMR spectroscopy.
    8. mutations in these domains did not affect the cleavage site selection of the enzyme, but affected cleavage efficiencies and dependence on magnesium ion concentrations
      Title: Mutational analyses of neighboring domains of active center of RNase P ribozyme.
    Submit: New GeneRIF Correction

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