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    pck phosphoenolpyruvate carboxykinase (ATP) [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945667, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pck
    Official Full Name
    phosphoenolpyruvate carboxykinase (ATP)
    Primary source
    ECOCYC:EG10688
    Locus tag
    b3403
    See related
    ASAP:ABE-0011106
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3390; pckA
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    Genomic context

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    Sequence:
    NC_000913.3 (3532818..3534440)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene molecular chaperone Hsp33 Neighboring gene putative transport protein YhgE Neighboring gene sensor histidine kinase EnvZ Neighboring gene DNA-binding transcriptional dual regulator OmpR Neighboring gene transcription elongation factor GreB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Escherichia coli phosphoenolpyruvate carboxykinase: a new structural family with the P-loop nucleoside triphosphate hydrolase fold. Matte A, et al. J Mol Biol, 1996 Feb 16. PMID 8609605
    2. Mechanisms of activation of phosphoenolpyruvate carboxykinase from Escherichia coli by Ca2+ and of desensitization by trypsin. Sudom A, et al. J Bacteriol, 2003 Jul. PMID 12837799, Free PMC Article
    3. Ligand interactions and protein conformational changes of phosphopyridoxyl-labeled Escherichia coli phosphoenolpyruvate carboxykinase determined by fluorescence spectroscopy. Encinas MV, et al. Eur J Biochem, 2002 Oct. PMID 12383254
    4. The phosphoryl-transfer mechanism of Escherichia coli phosphoenolpyruvate carboxykinase from the use of AlF(3). Sudom AM, et al. J Mol Biol, 2001 Nov 16. PMID 11724534
    5. Detection of an extended-10 element in the promoter region of the pckA gene encoding phosphoenolpyruvate carboxykinase in Escherichia coli. Prost JF, et al. Biochimie, 1999 Mar. PMID 10385000

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cAMP-CRP associated at downstream CRP box-2 plays as a repressor for pck transcription only in the presence of high levels of cAMP-CRP
      Title: Involvement of cAMP-CRP in transcription activation and repression of the pck gene encoding PEP carboxykinase, the key enzyme of gluconeogenesis.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxykinase (ATP)
    NP_417862.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3532818..3534440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417862.1 phosphoenolpyruvate carboxykinase (ATP) [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417862.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376LCK2, A0A8T3UJU3
      Conserved Domains (1) summary
      TIGR00224
      Location:3 → 540
      pckA; phosphoenolpyruvate carboxykinase (ATP)
    Nucleotide Protein
    Heading Accession and Version

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