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    pepQ Xaa-Pro dipeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948335, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pepQ
    Official Full Name
    Xaa-Pro dipeptidase
    Primary source
    ECOCYC:EG10698
    Locus tag
    b3847
    See related
    ASAP:ABE-0012569
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3839
    Summary
    PepQ, a proline dipeptidase, hydrolyzes dipeptide substrates containing a proline residue at the carboxy-terminal end. [More information is available at EcoCyc: EG10698].
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    Genomic context

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    Sequence:
    NC_000913.3 (4031161..4032492)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-ketoacyl-CoA thiolase Neighboring gene multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase Neighboring gene IMPACT family member YigZ Neighboring gene K(+) transporter TrkH Neighboring gene protoporphyrinogen oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of substrate selectivity of E. coli prolidase. Weaver J, et al. PLoS One, 2014. PMID 25354344, Free PMC Article
    2. Catalytic properties of the PepQ prolidase from Escherichia coli. Park MS, et al. Arch Biochem Biophys, 2004 Sep 15. PMID 15313226
    3. GroEL actively stimulates folding of the endogenous substrate protein PepQ. Weaver J, et al. Nat Commun, 2017 Jun 30. PMID 28665408, Free PMC Article
    4. Soluble di- and aminopeptidases in Escherichia K-12. Dispensible enzymes. Hermsdorf CL, et al. Int J Pept Protein Res, 1979 Feb. PMID 372108
    5. Nucleotide sequence between the fadB gene and the rrnA operon from Escherichia coli. Nakahigashi K, et al. Nucleic Acids Res, 1990 Nov 11. PMID 2243799, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric triester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptide catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Xaa-Pro dipeptidase
    NP_418289.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4031161..4032492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418289.1 Xaa-Pro dipeptidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418289.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1N4H2
      Conserved Domains (1) summary
      PRK13607
      Location:1 → 443
      PRK13607; proline dipeptidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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