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    srkA stress response kinase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948346, updated on 3-Dec-2024

    Summary

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    Official Symbol
    srkA
    Official Full Name
    stress response kinase A
    Primary source
    ECOCYC:EG11831
    Locus tag
    b3859
    See related
    ASAP:ABE-0012604
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3851; orfA; yihE
    Summary
    rdoA is required for long-term cell survival and for the expression of surface appendages (Zheng, 2007). [More information is available at EcoGene: EG11831]. YihE is a serine/threonine protein kinase that is able to autophosphorylate at serine and threonine, but not tyrosine residues. [More information is available at EcoCyc: EG11831].
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    Genomic context

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    Sequence:
    NC_000913.3 (4042415..4043401)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdopterin-guanine dinucleotide biosynthesis adaptor protein Neighboring gene molybdenum cofactor guanylyltransferase Neighboring gene DUF1040 domain-containing protein YihD Neighboring gene thiol:disulfide oxidoreductase DsbA Neighboring gene DUF945 domain-containing protein YihF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of the Shigella flexneri yihE gene in LPS synthesis and virulence. Edwards-Jones B, et al. Microbiology (Reading), 2004 Apr. PMID 15073317
    2. YihE kinase is a central regulator of programmed cell death in bacteria. Dorsey-Oresto A, et al. Cell Rep, 2013 Feb 21. PMID 23416055, Free PMC Article
    3. Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes. Plunkett G 3rd, et al. Nucleic Acids Res, 1993 Jul 25. PMID 8346018, Free PMC Article
    4. Salmonella enterica serovar typhimurium rdoA is growth phase regulated and involved in relaying Cpx-induced signals. Suntharalingam P, et al. J Bacteriol, 2003 Jan. PMID 12511488, Free PMC Article
    5. Influence of the yihE gene of Shigella flexneri on global gene expression: on analysis using DNA arrays. Li MS, et al. Biochem Biophys Res Commun, 2001 Oct 19. PMID 11594757

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stress response kinase A
    NP_418296.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4042415..4043401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418296.1 stress response kinase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418296.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X783, A0A8S7RCL1
      Conserved Domains (1) summary
      PRK11768
      Location:1 → 324
      PRK11768; serine/threonine protein kinase
    Nucleotide Protein
    Heading Accession and Version

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