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    metB O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948434, updated on 3-Dec-2024

    Summary

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    Official Symbol
    metB
    Official Full Name
    O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
    Primary source
    ECOCYC:EG10582
    Locus tag
    b3939
    See related
    ASAP:ABE-0012887
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3931; met-1
    Summary
    Upregulated by GSNO in defined medium. [More information is available at EcoGene: EG10582].
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    Genomic context

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    Sequence:
    NC_000913.3 (4128672..4129832)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipid-binding hydrolase YiiX Neighboring gene DNA-binding transcriptional repressor MetJ Neighboring gene fused aspartate kinase/homoserine dehydrogenase 2 Neighboring gene 5,10-methylenetetrahydrofolate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli. Wahl MC, et al. FEBS Lett, 1997 Sep 15. PMID 9323022
    2. Purification and properties of cystathionine gamma-synthase from overproducing strains of Escherichia coli. Holbrook EL, et al. Biochemistry, 1990 Jan 16. PMID 2405903
    3. Reaction mechanism of Escherichia coli cystathionine gamma-synthase: direct evidence for a pyridoxamine derivative of vinylglyoxylate as a key intermediate in pyridoxal phosphate dependent gamma-elimination and gamma-replacement reactions. Brzović P, et al. Biochemistry, 1990 Jan 16. PMID 2405904
    4. Cystathionine gamma-synthase from Salmonella. Beta elimination and replacement reactions and inhibition by O-succinylserine. Guggenheim S, et al. J Biol Chem, 1969 Jul 10. PMID 4893684
    5. Appendix. Purification, molecular weight, and NH2-terminal sequence of cystathionine gamma-synthase of Escherichia coli. Tran SV, et al. J Biol Chem, 1983 Dec 25. PMID 6361021

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cystathionine gamma-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine gamma-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine gamma-synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cystathionine gamma-synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process via cystathionine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase
    NP_418374.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4128672..4129832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418374.1 O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418374.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8H9W088
      Conserved Domains (1) summary
      PRK08045
      Location:1 → 386
      PRK08045; cystathionine gamma-synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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