thiH 2-iminoacetate synthase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: thiH
Official Full Name: 2-iminoacetate synthase
Primary source: ECOCYC:EG11590
Locus tag: b3990
See related: ASAP:ABE-0013048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3981; thiB
Summary: Anaerobically, glycine probably cannot be oxidized to form the probable thiamine biosynthetic intermediate dehydroglycine, so it is derived from tyrosine by the action of the tyrosine lyase ThiH; the products of the in vitro ThiH reaction are para-cresol and hydroglycine (Kriek, 2007). [More information is available at EcoGene: EG11590]. The ThiGH complex catalyzes the conversion of 1-deoxy-D-xylulose 5-phosphate to a thiazole as part of thiamine synthesis. [More information is available at EcoCyc: EG11590].
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NC_000913.3 Genomic Context describing neighboring genes

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Results describe the substrates and purified proteins required for Escherichia coli thiazole synthase subunits ThiG and ThiH in vitro.
Title: Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2-iminoacetate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-iminoacetate synthase activity	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in sulfur compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thiamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thiamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thiamine diphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in water-soluble vitamin biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 2-iminoacetate synthase complex	IPI Inferred from Physical Interaction more info	PubMed

NP_418417.1

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The following sections contain reference sequences that belong to a specific genome build. Explain