thiG 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: thiG
Official Full Name: 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase
Primary source: ECOCYC:EG11589
Locus tag: b3991
See related: ASAP:ABE-0013050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3982; thiB
Summary: The ThiG sequence has been confirmed using MS/MS: the measured mass of the intact protein is 26896.5 indicating that the initial Met is not clipped (Kelleher, 1998). [More information is available at EcoGene: EG11589]. The ThiGH complex catalyzes the conversion of 1-deoxy-D-xylulose 5-phosphate to a thiazole as part of thiamine synthesis. [More information is available at EcoCyc: EG11589].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Results describe the substrates and purified proteins required for Escherichia coli thiazole synthase subunits ThiG and ThiH in vitro.
Title: Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfurtransferase activity	IEA Inferred from Electronic Annotation more info
enables thiazole synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in thiamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thiamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thiamine diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiamine diphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in thiamine diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 2-iminoacetate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of 2-iminoacetate synthase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_418418.2

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The following sections contain reference sequences that belong to a specific genome build. Explain