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    dusA tRNA-dihydrouridine synthase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948558, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dusA
    Official Full Name
    tRNA-dihydrouridine synthase A
    Primary source
    ECOCYC:EG11932
    Locus tag
    b4049
    See related
    ASAP:ABE-0013258
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4041; yjbN
    Summary
    DusA is a tRNA-dihydrouridine synthase and accounts for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusB and DusC together account for the other half . [More information is available at EcoCyc: EG11932].
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    Genomic context

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    Sequence:
    NC_000913.3 (4261669..4262706)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YjbL Neighboring gene DUF2713 domain-containing protein YjbM Neighboring gene phage shock protein G Neighboring gene ncRNA Neighboring gene putative quinone oxidoreductase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular determinants of dihydrouridine synthase activity. Savage DF, et al. FEBS Lett, 2006 Oct 2. PMID 16962594
    2. Identification of the tRNA-dihydrouridine synthase family. Bishop AC, et al. J Biol Chem, 2002 Jul 12. PMID 11983710
    3. Thermofluor-based high-throughput stability optimization of proteins for structural studies. Ericsson UB, et al. Anal Biochem, 2006 Oct 15. PMID 16962548
    4. Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Blattner FR, et al. Nucleic Acids Res, 1993 Nov 25. PMID 8265357, Free PMC Article
    5. Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Zhang N, et al. Proteomics, 2007 Feb. PMID 17309111

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA-dihydrouridine20 synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine20a synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA dihydrouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA-dihydrouridine synthase A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4261669..4262706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418473.3 tRNA-dihydrouridine synthase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418473.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ANY6, A0A7I6H8M4, A7ZUS0
      Conserved Domains (1) summary
      PRK11815
      Location:16 → 344
      PRK11815; tRNA dihydrouridine(20/20a) synthase DusA
    Nucleotide Protein
    Heading Accession and Version

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