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    frdB fumarate reductase iron-sulfur protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948666, updated on 3-Dec-2024

    Summary

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    Official Symbol
    frdB
    Official Full Name
    fumarate reductase iron-sulfur protein
    Primary source
    ECOCYC:EG10331
    Locus tag
    b4153
    See related
    ASAP:ABE-0013602
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4149
    Summary
    HT_Cmplx15_Mem: [More information is available at EcoGene: EG10331]. This is one of two catalytic subunits of the four subunit enzyme. [More information is available at EcoCyc: EG10331].
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    Genomic context

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    Sequence:
    NC_000913.3 (4379783..4380517, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarate reductase membrane protein FrdD Neighboring gene fumarate reductase membrane protein FrdC Neighboring gene fumarate reductase flavoprotein subunit Neighboring gene EF-P-lysine lysyltransferase Neighboring gene putative transporter YjeM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [3Fe-4S] to [4Fe-4S] cluster conversion in Escherichia coli fumarate reductase by site-directed mutagenesis. Manodori A, et al. Biochemistry, 1992 Mar 17. PMID 1312345
    2. Site-directed mutagenesis of conserved cysteine residues in Escherichia coli fumarate reductase: modification of the spectroscopic and electrochemical properties of the [2Fe-2S] cluster. Werth MT, et al. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2174169, Free PMC Article
    3. Effect of cysteine to serine mutations on the properties of the [4Fe-4S] center in Escherichia coli fumarate reductase. Kowal AT, et al. Biochemistry, 1995 Sep 26. PMID 7547971
    4. In vivo detection of a three iron cluster in fumarate reductase from Escherichia coli. Johnson MK, et al. Biochem Biophys Res Commun, 1985 Sep 16. PMID 2996520
    5. Detection of a tetranuclear iron-sulfur center in fumarate reductase from Escherichia coli by electron paramagnetic resonance spectroscopy. Johnson MK, et al. Biochem Biophys Res Commun, 1985 Sep 16. PMID 2996525

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Location and nucleotide sequence of frdB, the gene coding for the iron-sulphur protein subunit of the fumarate reductase of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic electron transport chain NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in anaerobic respiration EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bacterial-type flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fermentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of fumarate reductase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of fumarate reductase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fumarate reductase iron-sulfur protein
    NP_418577.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4379783..4380517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418577.1 fumarate reductase iron-sulfur protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418577.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2Z654
      Conserved Domains (1) summary
      PRK12385
      Location:1 → 244
      PRK12385; succinate dehydrogenase/fumarate reductase iron-sulfur subunit
    Nucleotide Protein
    Heading Accession and Version

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