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    ulaG L-ascorbate-6-phosphate lactonase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948705, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ulaG
    Official Full Name
    L-ascorbate-6-phosphate lactonase
    Primary source
    ECOCYC:G7855
    Locus tag
    b4192
    See related
    ASAP:ABE-0013717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4188; yjfR
    Summary
    UlaG has phosphodiesterase activity with model substrate bis-pNPPAFMB (Kuznetsova, 2005). [More information is available at EcoGene: EG12492]. UlaG is required for the ability to utilize L-ascorbate as the sole carbon source under anaerobic growth conditions. [More information is available at EcoCyc: G7855].
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    Genomic context

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    Sequence:
    NC_000913.3 (4418561..4419625, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1471 domain-containing putative lipoprotein BsmA Neighboring gene carboxylesterase Neighboring gene DNA-binding transcriptional repressor UlaR Neighboring gene L-ascorbate specific PTS enzyme IIC component Neighboring gene L-ascorbate specific PTS enzyme IIB component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular architecture of the Mn2+-dependent lactonase UlaG reveals an RNase-like metallo-beta-lactamase fold and a novel quaternary structure. Garces F, et al. J Mol Biol, 2010 May 21. PMID 20359483
    2. Overproduction, crystallization and preliminary X-ray analysis of the putative L-ascorbate-6-phosphate lactonase UlaG from Escherichia coli. Garces F, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Jan 1. PMID 18097099, Free PMC Article
    3. Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals. Huerta AM, et al. J Mol Biol, 2003 Oct 17. PMID 14529615
    4. Novel ligands for the extracellular solute receptors of two bacterial TRAP transporters. Thomas GH, et al. Microbiology (Reading), 2006 Jan. PMID 16385129
    5. The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli. Campos E, et al. J Bacteriol, 2002 Nov. PMID 12374842, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-ascorbate 6-phosphate lactonase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-ascorbate 6-phosphate lactonase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-ascorbic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-ascorbic acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-ascorbate-6-phosphate lactonase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4418561..4419625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418613.2 L-ascorbate-6-phosphate lactonase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418613.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3HXW1, A0A1X3J7B2, A0A5B9ALW8, A0A829L917, A0AAJ3TZ42, A0AAN3MA83, C3SFU7
      Conserved Domains (1) summary
      PRK11709
      Location:1 → 354
      PRK11709; putative L-ascorbate 6-phosphate lactonase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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