U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hpt hypoxanthine phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946624, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hpt
    Official Full Name
    hypoxanthine phosphoribosyltransferase
    Primary source
    ECOCYC:EG20098
    Locus tag
    b0125
    See related
    ASAP:ABE-0000440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0124
    Summary
    Hypoxanthine phosphoribosyltransferase is a purine salvage enzyme whose primary activity is with hypoxanthine as the substrate . [More information is available at EcoCyc: EG20098].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (141431..141967)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multicopper oxidase CueO Neighboring gene quinoprotein glucose dehydrogenase Neighboring gene carbonic anhydrase 2 Neighboring gene putative ABC transporter ATP-binding protein YadG Neighboring gene putative ABC transporter membrane subunit YadH

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hypoxanthine phosphoribosyltransferase and guanine phosphoribosyltransferase from enteric bacteria. Hochstadt J. Methods Enzymol, 1978. PMID 692401
    2. Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase. Scism RA, et al. Org Lett, 2007 Oct 11. PMID 17854193
    3. Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Guddat LW, et al. Protein Sci, 2002 Jul. PMID 12070315, Free PMC Article
    4. [Genetic study of the mutations impairing guanine, xanthine and hypoxanthines assimilation in a purine auxotroph of Escherichia coli K-12]. Brikun IA, et al. Genetika, 1981. PMID 7014364
    5. The location of purine phosphoribosyltransferase activities in Escherichia coli. Page MG, et al. Biochem J, 1978 Sep 15. PMID 365172, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hypoxanthine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hypoxanthine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hypoxanthine phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within GMP salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within GMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in IMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within IMP salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within IMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in guanine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hypoxanthine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    hypoxanthine phosphoribosyltransferase
    NP_414667.4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      141431..141967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414667.4 hypoxanthine phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414667.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D6I022, A0A0E2LPG6, S1NXE0
      Conserved Domains (1) summary
      PRK15423
      Location:1 → 178
      PRK15423; hypoxanthine phosphoribosyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.