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    glnD protein-PII uridylyltransferase/uridylyl-removing enzyme [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944863, updated on 3-Dec-2024

    Summary

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    Official Symbol
    glnD
    Official Full Name
    protein-PII uridylyltransferase/uridylyl-removing enzyme
    Primary source
    ECOCYC:EG11411
    Locus tag
    b0167
    See related
    ASAP:ABE-0000568
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0165; glnD5
    Summary
    GlnD has both a uridylyltransferase and a uridylyl-removing activity. [More information is available at EcoGene: EG11411]. Uridylyltransferase is a single polypeptide chain. [More information is available at EcoCyc: EG11411].
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    Genomic context

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    Sequence:
    NC_000913.3 (185978..188650, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphodiesterase YaeI Neighboring gene tetrahydrodipicolinate succinylase Neighboring gene methionine aminopeptidase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of glutamine synthetase formation in Escherichia coli: characterization of mutants lacking the uridylyltransferase. Bloom FR, et al. J Bacteriol, 1978 May. PMID 26660, Free PMC Article
    2. Localization of the glnD gene on a revised map of the 200-kilobase region of the Escherichia coli chromosome. van Heeswijk W, et al. J Bacteriol, 1992 Mar. PMID 1537813, Free PMC Article
    3. The Escherichia coli PII signal transduction protein is activated upon binding 2-ketoglutarate and ATP. Kamberov ES, et al. J Biol Chem, 1995 Jul 28. PMID 7629080
    4. Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme. Garcia E, et al. J Biol Chem, 1983 Feb 25. PMID 6130097
    5. Characterization of a gene, glnL, the product of which is involved in the regulation of nitrogen utilization in Escherichia coli. Chen YM, et al. J Bacteriol, 1982 Apr. PMID 6120930, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-gamma-glutamate synthase FolC.
      Title: The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-γ-glutamate synthase FolC.
    2. investigation of regulation of UR-PII-ATase-GS bicyclic system: Data suggest that AT activity is only bound/activated by completely unmodified PII and that this design is largely responsible for ultrasensitivity of bicyclic system.
      Title: A source of ultrasensitivity in the glutamine response of the bicyclic cascade system controlling glutamine synthetase adenylylation state and activity in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables [protein-PII] uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [protein-PII] uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables [protein-PII] uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [protein-PII] uridylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of nitrogen utilization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of nitrogen utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-PII uridylyltransferase/uridylyl-removing enzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      185978..188650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414709.1 protein-PII uridylyltransferase/uridylyl-removing enzyme [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414709.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QVZ6
      Conserved Domains (1) summary
      PRK05007
      Location:7 → 890
      PRK05007; bifunctional uridylyltransferase/uridylyl-removing protein GlnD
    Nucleotide Protein
    Heading Accession and Version

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