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    dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945019, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dxr
    Official Full Name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Primary source
    ECOCYC:EG12715
    Locus tag
    b0173
    See related
    ASAP:ABE-0000592
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0172; ispC; yaeM
    Summary
    1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) catalyzes the first committed step in the methylerythritol phosphate pathway of isoprenoid biosynthesis. [More information is available at EcoCyc: EG12715].
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    Genomic context

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    Sequence:
    NC_000913.3 (193521..194717)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UMP kinase Neighboring gene ribosome-recycling factor Neighboring gene ncRNA Neighboring gene ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Mercklé L, et al. Chembiochem, 2005 Oct. PMID 16116659
    2. Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding. Yajima S, et al. J Biochem, 2002 Mar. PMID 11872159
    3. Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Hoeffler JF, et al. Eur J Biochem, 2002 Sep. PMID 12230556
    4. Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. Steinbacher S, et al. J Biol Chem, 2003 May 16. PMID 12621040
    5. High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition. Gottlin EB, et al. J Biomol Screen, 2003 Jun. PMID 12857387

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair.
      Title: Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair.
    2. Data indicate that IspC (1-deoxy-D-xylulose 5-phosphate reductoisomerase) displays a high level of enantioselectivity for an alpha-substituted fosmidomycin derivative.
      Title: IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
    3. chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase
      Title: The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Dxr protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
    NP_414715.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      193521..194717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414715.1 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414715.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L5GZ07, A0A5B9AL13, A0A8S7RUP4
      Conserved Domains (1) summary
      TIGR00243
      Location:1 → 398
      Dxr; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Nucleotide Protein
    Heading Accession and Version

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