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    gloB hydroxyacylglutathione hydrolase GloB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944902, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gloB
    Official Full Name
    hydroxyacylglutathione hydrolase GloB
    Primary source
    ECOCYC:G6099
    Locus tag
    b0212
    See related
    ASAP:ABE-0000707
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0212; yafR
    Summary
    OtherPDB (S.typhimurium): [More information is available at EcoGene: EG13330]. Glyoxalase II catalyzes the second of two sequential reactions in the conversion of methylglyoxal to D-lactate . [More information is available at EcoCyc: G6099].
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    Genomic context

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    Sequence:
    NC_000913.3 (234027..234782, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative S-adenosylmethionine-dependent methyltransferase Neighboring gene membrane-bound lytic murein transglycosylase D Neighboring gene protein YkfO Neighboring gene putative S-adenosyl-L-methionine-dependent methyltransferase Neighboring gene ribonuclease HI Neighboring gene DNA polymerase III subunit epsilon

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione. Misra K, et al. Biochem J, 1995 Feb 1. PMID 7848303, Free PMC Article
    2. The role of alpha,beta -dicarbonyl compounds in the toxicity of short chain sugars. Okado-Matsumoto A, et al. J Biol Chem, 2000 Nov 10. PMID 10931845
    3. The formation and catabolism of methylglyoxal during glycolysis in Escherichia coli. Cooper RA, et al. FEBS Lett, 1970 Dec 11. PMID 11945504
    4. Excretion of glutathione by methylglyoxal-resistant Escherichia coli. Murata K, et al. J Gen Microbiol, 1980 Oct. PMID 7014775
    5. Metabolism of methylglyoxal in microorganisms. Cooper RA. Annu Rev Microbiol, 1984. PMID 6093685

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacylglutathione hydrolase GloB
    NP_414748.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      234027..234782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414748.1 hydroxyacylglutathione hydrolase GloB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414748.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TQA1
      Conserved Domains (1) summary
      PRK10241
      Location:1 → 251
      PRK10241; hydroxyacylglutathione hydrolase; Provisional
    Nucleotide Protein
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