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    betB betaine aldehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947376, updated on 17-Dec-2024

    Summary

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    Official Symbol
    betB
    Official Full Name
    betaine aldehyde dehydrogenase
    Primary source
    ECOCYC:EG10110
    Locus tag
    b0312
    See related
    ASAP:ABE-0001072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0310
    Summary
    The bet genes are induced by choline, oxygen, and osmotic stress. [More information is available at EcoGene: EG10110].
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    Genomic context

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    Sequence:
    NC_000913.3 (327261..328733, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YkgH Neighboring gene choline dehydrogenase Neighboring gene DNA-binding transcriptional repressor BetI Neighboring gene choline:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overproduction of spinach betaine aldehyde dehydrogenase in Escherichia coli. Structural and functional properties of wild-type, mutants and E. coli enzymes. Incharoensakdi A, et al. Eur J Biochem, 2000 Dec. PMID 11106411
    2. Induction of the L-arabinose operon. Schleif R. J Mol Biol, 1969 Nov 28. PMID 4902209
    3. Choline-glycine betaine pathway confers a high level of osmotic tolerance in Escherichia coli. Landfald B, et al. J Bacteriol, 1986 Mar. PMID 3512525, Free PMC Article
    4. Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli. Falkenberg P, et al. Biochim Biophys Acta, 1990 Jun 20. PMID 2194570
    5. Characterization of an Escherichia coli gene encoding betaine aldehyde dehydrogenase (BADH): structural similarity to mammalian ALDHs and a plant BADH. Boyd LA, et al. Gene, 1991 Jul 15. PMID 1879697

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables betaine-aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables betaine-aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables betaine-aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycine betaine biosynthetic process from choline IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine betaine biosynthetic process from choline IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    betaine aldehyde dehydrogenase
    NP_414846.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      327261..328733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414846.1 betaine aldehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414846.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6A167, A7LLT9
      Conserved Domains (1) summary
      PRK13252
      Location:1 → 490
      PRK13252; betaine aldehyde dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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