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    prpB 2-methylisocitrate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944990, updated on 3-Dec-2024

    Summary

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    Official Symbol
    prpB
    Official Full Name
    2-methylisocitrate lyase
    Primary source
    ECOCYC:G6196
    Locus tag
    b0331
    See related
    ASAP:ABE-0001138
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0329; yahQ
    Summary
    Repressed during biofilm formation. [More information is available at EcoGene: EG13601]. PrpB catalyzes the final step in the propionate metabolism pathway . [More information is available at EcoCyc: G6196].
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    Genomic context

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    Sequence:
    NC_000913.3 (348682..349572)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1471 domain-containing protein YahO Neighboring gene DNA-binding transcriptional dual regulator PrpR Neighboring gene 2-methylcitrate synthase Neighboring gene 2-methylcitrate dehydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution. Liu S, et al. Biochemistry, 2005 Mar 1. PMID 15723538
    2. Crystal structure of Salmonella typhimurium 2-methylisocitrate lyase (PrpB) and its complex with pyruvate and Mg(2+). Simanshu DK, et al. Biochem Biophys Res Commun, 2003 Nov 7. PMID 14575713
    3. Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre. Grimm C, et al. J Mol Biol, 2003 May 2. PMID 12706720
    4. 2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes. Brock M, et al. Eur J Biochem, 2001 Jun. PMID 11422389
    5. Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein. Lee SK, et al. J Bacteriol, 2005 Apr. PMID 15805526, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylisocitrate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylisocitrate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylisocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxo-acid-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in propionate catabolic process, 2-methylcitrate cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within propionate catabolic process, 2-methylcitrate cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in propionate catabolic process, 2-methylcitrate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-methylisocitrate lyase
    NP_414865.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      348682..349572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414865.1 2-methylisocitrate lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414865.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GDI3
      Conserved Domains (1) summary
      PRK11320
      Location:2 → 292
      prpB; 2-methylisocitrate lyase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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